Art. -Nr.: HY-N1478

Gardenoside

2 Cited Publications

Kundenbewertung

Based on 2 publication(s) in Google Scholar

Gardenoside is an orally active natural compound found in Gardenia fruits. Gardenoside reliefs chronic constriction injury (CCI)-induced neuropathic pain by regulating the P2X3 and P2X7 receptors. Gardenoside has an inhibitory effect on free fatty acids (FFA)-induced cellular steatosis. Gardenoside reduces reactive oxygen species (ROS). Gardenoside can be used for anti-inflammatory, antinociceptive and hepatoprotective study.

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Reinheit: 99.85%
CAS. Nr.: 24512-62-7
Formel: C₁₇H₂₄O₁₁
Molecular Weight:404.37

Speicherung:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Gardenoside Chemical Structure

CAS. Nr.: 24512-62-7

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Publications (2)
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

P2X3 Receptor

P2X7 Receptor

Alle P2X Receptor Isoform-spezifische Produkte anzeigen :

In Vitro

Gardenoside (10-20 μM, 24 h) can decrease the lipid droplets in HepG2 cells cultured with Palmitic acid (PA) (HY-N0830) and Oleic acid (OA) (HY-N1446)^[2].
Gardenoside (10-20 μM, 24 h) decreases TNF-α, IL-6, IL-1βinduced by free fatty acids (FFAs) in HepG2 cells^[2].
Gardenoside (10 μM) suppress the IL-1β-induced inflammatory reaction and ROS level in chondrocytes^[3].
Gardenoside (10 μM) protects chondrocyte via inhibiting NF-κB/IκBα signaling pathways in chondrocytes^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis^[2]

Cell Line:

HepG2 cells
Concentration:

10, 20 μM
Incubation Time:

24 h
Result:

Decreased Phospho-NFκB p65 induced by FFAs in HepG2 cells.

In Vivo

Gardenoside (300 μM; p.o.; daily for 14 d) reliefs chronic constriction injury (CCI)-induced neuropathic pain by regulating the P2X3 and the P2X7 expression on the ischiadic nerve in Sprague Dawley rats^[1].
Gardenoside (1 mg/kg; Intra-articular injections; daily for one week, then once every three days for another three weeks) attenuates osteoarthritis (OA) progression in rats^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Male Sprague-Dawley rats (200g)^[3]
Dosage:

1 mg/kg
Administration:

Intra-articular injections; daily for one week, then once every three days for another three weeks.
Result:

Attenuates OA progression in rats.

Animal Model:

Male Sprague Dawley rats (8-10 weeks)^[1]
Dosage:

300 μM with 1% sodium carboxymethyl cellulose (5 mL)
Administration:

Oral gavage (p.o.); daily for 14 d
Result:

Partially restore the decrease of the MWT and TWL by sciatic nerve CCI.
Decreased the inflammation after sciatic nerve CCI.
Inhibited the up-expression of P2X3 and P2X7 receptors induced by sciatic nerve CCI.
Inhibited the expression of p-ERK and p-p38 induced by sciatic nerve CCI.

Chemical Information

CAS. Nr. 24512-62-7
Appearance Solid
Molecular Weight 404.37
Formel C₁₇H₂₄O₁₁
Color Off-white to light yellow
SMILES

O=C(C1=CO[C@@H](O[C@H]2[C@@H]([C@H]([C@@H]([C@@H](CO)O2)O)O)O)[C@@]3([H])[C@]1([H])C=C[C@@]3(O)CO)OC
Structure Classification
- Terpenoids
- Iridoids
Initial Source
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Publications (2)

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Journal Impact Factor

Int Immunopharmacol

Rutin ameliorates hepatic ischemia-reperfusion injury by targeting CD36 to suppress hepatocyte ferroptosis. [Abstract]

2026 Mar 1:172:116231. PMID: 41576568
Microbiol Spectr

Gardenoside attenuates Staphylococcus aureus-induced mastitis by inhibiting inflammation and ferroptosis through Nrf2/SLC7A11/GPX4 signaling pathway. [Abstract]

2024 Nov 29:e0226224. PMID: 39612214

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 100 mg/mL (247.30 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.4730 mL

12.3649 mL

24.7298 mL

5 mM

0.4946 mL

2.4730 mL

4.9460 mL

10 mM

0.2473 mL

1.2365 mL

2.4730 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.5 mg/mL (6.18 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.5 mg/mL (6.18 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (6.18 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (283 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Yu M, Su B, et al. Gardenoside suppresses the pain in rats model of chronic constriction injury by regulating the P2X3 and P2X7 receptors. J Recept Signal Transduct Res. 2018 Jun;38(3):198-203. [Content Brief]

[2]. Liang H, et al. Inhibitory Effect of Gardenoside on Free Fatty Acid-Induced Steatosis in HepG2 Hepatocytes. Int J Mol Sci. 2015 Nov 20;16(11):27749-56. [Content Brief]

[3]. Xia T, et al. Gardenoside ameliorates inflammation and inhibits ECM degradation in IL-1β-treated rat chondrocytes via suppressing NF-κB signaling pathways. Biochem Biophys Res Commun. 2023 Jan 15;640:164-172. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.4730 mL	12.3649 mL	24.7298 mL	61.8246 mL
	5 mM	0.4946 mL	2.4730 mL	4.9460 mL	12.3649 mL
	10 mM	0.2473 mL	1.2365 mL	2.4730 mL	6.1825 mL
	15 mM	0.1649 mL	0.8243 mL	1.6487 mL	4.1216 mL
	20 mM	0.1236 mL	0.6182 mL	1.2365 mL	3.0912 mL
	25 mM	0.0989 mL	0.4946 mL	0.9892 mL	2.4730 mL
	30 mM	0.0824 mL	0.4122 mL	0.8243 mL	2.0608 mL
	40 mM	0.0618 mL	0.3091 mL	0.6182 mL	1.5456 mL
	50 mM	0.0495 mL	0.2473 mL	0.4946 mL	1.2365 mL
	60 mM	0.0412 mL	0.2061 mL	0.4122 mL	1.0304 mL
	80 mM	0.0309 mL	0.1546 mL	0.3091 mL	0.7728 mL
	100 mM	0.0247 mL	0.1236 mL	0.2473 mL	0.6182 mL

Keywords

Gardenoside

2 Cited Publications

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Gardenoside

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Publications Citing Use of MedChemExpress (MCE) Gardenoside

Alle P2X Receptor Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Publications (2)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Gardenoside Related Classifications

HY-N1478 Related Classifications