GEBR-7b
GEBR-7b is a selective PDE4D inhibitor with an IC50 of 0.67 μM. GEBR-7b increases hippocampal cAMP and does not influence Aβ levels in rodents. GEBR-7b also improves spatial and can be used for the study of cognitive deficits.
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- CAS. Nr.: 1776944-03-6
- Formel: C21H30N2O5
- Molecular Weight:390.47
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Biologische Aktivität
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Sf9 | IC50 |
0.67 μM
Compound: 7b
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Inhibition of human recombinant PDE4D expressed in Sf9 cells
Inhibition of human recombinant PDE4D expressed in Sf9 cells
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[PMID: 19827751] |
Chemical Information
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CAS. Nr. 1776944-03-6
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Molecular Weight 390.47
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Formel C21H30N2O5
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SMILES
COC1=CC=C(C=C1OC2CCCC2)/C=N/OCC(N3CC(C)OC(C)C3)=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Bruno O, et al. New selective phosphodiesterase 4D inhibitors differently acting on long, short, and supershort isoforms. J Med Chem. 2009 Nov 12;52(21):6546-57. [Content Brief]
[2]. Bruno O, et al. GEBR-7b, a novel PDE4D selective inhibitor that improves memory in rodents at non-emetic doses. Br J Pharmacol. 2011 Dec;164(8):2054-63. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
GEBR-7b Related Classifications
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