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EIF4A1 - eukaryotic translation initiation factor 4A1 Gene

Also Known as DDX2A; EIF4A; EIF-4A; eIF4A-I; eIF-4A-I

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 1973

About EIF4A1

Cytogenetic location: 17p13.1 Genomic coordinates (GRCh38): 17:7,572,825-7,579,006 (from NCBI)

This gene has 36 transcripts (splice variants), 131 orthologues and 38 paralogues. Ubiquitous expression in appendix (RPKM 182.3), bone marrow (RPKM 177.5) and 25 other tissues.

Summary

Enables double-stranded RNA binding activity. Predicted to be involved in cytoplasmic translational initiation. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

EIF4A1 Products (2)

mRNA	Protein	Name
NM_001204510.2	NP_001191439.1	eukaryotic initiation factor 4A-I isoform 2
NM_001416.4	NP_001407.1	eukaryotic initiation factor 4A-I isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables double-stranded RNA binding	IDA IDA: Inferred from direct assay	21266579	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9548260	GOA
enables translation initiation factor activity	IDA IDA: Inferred from direct assay	34731628	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
involved in cytoplasmic translational initiation	IDA IDA: Inferred from direct assay	34731628	GOA
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	20156963	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	12426392	GOA
located in nuclear stress granule	IDA IDA: Inferred from direct assay	20156963	GOA
NOT located in nucleus	IDA IDA: Inferred from direct assay	12426392	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	20156963	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	20156963	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EIF4A1 Protein Structure

DEAD

Helicase_C

0
100
200
300
406 a.a.

Protein Preferred Names	Protein Names
eukaryotic initiation factor 4A-I	ATP-dependent RNA helicase eIF4A-1

EIF4A1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	EIF4A1	P60842	EIF4G2	Homo sapiens	P78344	Anti Tag CoIP	35271311
Intra	EIF4A1	P60842	EIF4G2	Homo sapiens	P78344	Anti Tag CoIP	16932749
Intra	EIF4A1	P60842	EIF4G2	Homo sapiens	P78344	Pull Down	16166382
Intra	EIF4A1	P60842	EIF4G2	Homo sapiens	P78344	Anti Tag CoIP	33961781
Intra	EIF4A1	P60842	EIF4G1	Homo sapiens	Q04637-1	DLS	18606994
Intra	EIF4A1	P60842	EIF4G1	Homo sapiens	Q04637-1	GMS	18606994
Intra	EIF4A1	P60842	EIF4G1	Homo sapiens	Q04637	Anti Tag CoIP	33961781
Intra	EIF4A1	P60842	EIF4G1	Homo sapiens	Q04637	DLS	18606994
Intra	EIF4A1	P60842	EIF4G1	Homo sapiens	Q04637	SPR	19203580
Intra	EIF4A1	P60842	EIF4G1	Homo sapiens	Q04637	ITC	23478064
Intra	EIF4A1	P60842	EIF4G1	Homo sapiens	Q04637	Anti Tag CoIP	23023399
Intra	EIF4A1	P60842	EIF4G1	Homo sapiens	Q04637	GMS	18606994
Intra	EIF4A1	P60842	EIF4G1	Homo sapiens	Q04637	Anti Tag CoIP	16932749
Intra	EIF4A1	P60842	EIF4G1	Homo sapiens	Q04637	GMS	23478064
Intra	EIF4A1	P60842	EIF4G1	Homo sapiens	Q04637	Pull Down	16932749
Intra	EIF4A1	P60842	PDCD4	Homo sapiens	Q53EL6	NMR	18296639
Intra	EIF4A1	P60842	PDCD4	Homo sapiens	Q53EL6	Anti Bait CoIP	17353931
Intra	EIF4A1	P60842	PDCD4	Homo sapiens	Q53EL6	ITC	19204291
Intra	EIF4A1	P60842	PDCD4	Homo sapiens	Q53EL6	X-Ray Diffraction	19204291
Intra	EIF4A1	P60842	PDCD4	Homo sapiens	Q53EL6	Anti Bait CoIP	24413684
Intra	EIF4A1	P60842	PDCD4	Homo sapiens	Q53EL6	SPR	18296639
Intra	EIF4A1	P60842	PDCD4	Homo sapiens	Q53EL6	Anti Tag CoIP	33961781
Intra	EIF4A1	P60842	PDCD4	Homo sapiens	Q53EL6	GMS	19204291
Intra	EIF4A1	P60842	PDCD4	Homo sapiens	Q53EL6	Anti Tag CoIP	28514442
Intra	EIF4A1	P60842	PDCD4	Homo sapiens	Q53EL6	Solution Sedimentation	19204291

Cross: Cross-species interaction Intra: Intraspecies interaction

EIF4A1 Antibodies

Art. -Nr.	Produktname	Anwendung	Reactivity
HY-P80650	eIF4A1 Antibody (YA774)	WB, IHC-F, IHC-P, ICC/IF	Human, Mouse, Rat
HY-P85680	eIF4A1 Antibody (YA5372)	WB, IHC-P, ICC/IF	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Fragile X Syndrome	FXS Martin-Bell Syndrome Fraxa Syndrome Marker X Syndrome X-Linked Mental Retardation And Macroorchidism Fragile X Mental Retardation Syndrome Fra Syndrome Mental Retardation, X-Linked, Associated With Marxq28 X-Linked Intellectual Disability And Macroorchidism Frax Syndrome Symptomatic Form Of Fragile X Syndrome In Female Carriers Fragile-X Syndrome Fraxe Syndrome
Fragile X-Associated Tremor/Ataxia Syndrome	Fxtas Syndrome Fragile X Tremor/Ataxia Syndrome Fxtas
Spinocerebellar Ataxia 8	Spinocerebellar Ataxia Type 8 SCA8 Ataxia, Spinocerebellar, Type 8

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (17)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-19560	SBI-0640756	Inhibitor	99.75%	Unkown
HY-RS04277	EIF4EBP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-176844	eIF4A-IN-1 intermediate		/	Unkown
HY-RS04270	EIF4A1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS04281	EIF4G1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-164524	SBI-0640726	Inhibitor	/	Unkown
HY-129768	CMLD012072	Inhibitor	/	Unkown
HY-129769	CMLD012073	Inhibitor	/	Unkown
HY-145240	eIF4E-IN-1	Inhibitor	/	Unkown
HY-176842	eIF4A-IN-1	Inhibitor	/	Unkown
HY-RS04280	EIF4ENIF1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19254	Eif4g1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20153	Eif4a1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20227	Eif4ebp1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25743	Eif4g1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26657	Eif4a1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26734	Eif4ebp1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	EIF4A1	RGD	RGD:735141
Felis catus	EIF4A1	VGNC	VGNC:98947
Mus musculus	EIF4A1	MGD	MGI:95303
Bos taurus	EIF4A1	VGNC	VGNC:28404
Macaca mulatta	EIF4A1	VGNC	VGNC:99145
Others	EIF4A1	NCBI