ELK1 - ETS transcription factor ELK1 Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 2002

About ELK1

Cytogenetic location: Xp11.23 Genomic coordinates (GRCh38): X:47,635,520-47,650,604 (from NCBI)

This gene has 4 transcripts (splice variants), 179 orthologues and 28 paralogues. Ubiquitous expression in ovary (RPKM 19.1), brain (RPKM 15.9) and 25 other tissues.

Summary

This gene is a member of the Ets family of transcription factors and of the ternary complex factor (TCF) subfamily. Proteins of the TCF subfamily form a ternary complex by binding to the the serum response factor and the serum response element in the promoter of the c-Fos proto-oncogene. The protein encoded by this gene is a nuclear target for the ras-raf-MAPK signaling cascade. This gene produces multiple isoforms by using alternative translational start codons and by alternative splicing. Related pseudogenes have been identified on chromosomes 7 and 14. [provided by RefSeq, Mar 2012]

ELK1 Products (3)

mRNA	Protein	Name
NM_001114123.3	NP_001107595.1	ETS domain-containing protein Elk-1 isoform a
NM_001257168.1	NP_001244097.1	ETS domain-containing protein Elk-1 isoform b
NM_005229.4	NP_005220.2	ETS domain-containing protein Elk-1 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	12750007	GOA
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	14970218	GOA
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	10799319	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	12750007	GOA
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	26612202	GOA
enables nuclear receptor coactivator activity	IMP IMP: Inferred from mutant phenotype	31146003	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16291755	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	31146003	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
acts upstream of or within positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	15790681	GOA
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	17296730	GOA
involved in positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	31146003	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	12750007	GOA
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	22065586	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
located in nucleus	IDA IDA: Inferred from direct assay	20018936	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ELK1 Protein Structure

Ets

0
100
200
300
400
428 a.a.

Protein Preferred Names	Protein Names
ETS domain-containing protein Elk-1	ELK1, ETS transcription factor

ELK1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	ELK1	P19419	FOXE1	Homo sapiens	O00358	Gal4 VP16 Complement	27852061
Intra	ELK1	P19419	FOXE1	Homo sapiens	O00358	Anti Bait CoIP	27852061
Intra	ELK1	P19419	MAPK3	Homo sapiens	P27361	Protein Kinase Assay	16291755
Intra	ELK1	P19419	MAPK3	Homo sapiens	P27361	PLA	25241761
Intra	ELK1	P19419	SUMO1	Homo sapiens	P63165	Anti Tag CoIP	17036045
Intra	ELK1	P19419	UBE2I	Homo sapiens	P63279	Anti Bait CoIP	17036045

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant ELK1 Proteins

Art. -Nr.	Produktname	Accession	Reinheit
HY-P74176	ELK1 Protein, Human (sf9, His-GST)	P19419-1 (M1-P428)	≥ 80%, as determined by reducing SDS-PAGE.

ELK1 Antibodies

Art. -Nr.	Produktname	Anwendung	Reactivity
HY-P810618	Phospho-ELK1 (Ser383) Antibody (YA9880)	WB, IHC-P, IP	Human, Mouse
HY-P83013	ELK1 Antibody (YA2758)	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat
HY-P83013A	ELK1 Antibody (YA2758)(PBS only)	WB, IHC-P, IP, ChIP	Human
HY-P85134	ELK1 Antibody (YA4826)	WB, IHC-P, ICC/IF, ELISA	Human

Related Diseases

Diseases	Alias
Prion Disease	Spongiform Encephalopathy Transmissible Spongiform Encephalopathies Prion Diseases Prion Disease Pathway Transmissible Spongiform Encephalopathy Prion Induced Disorder Prion Protein Disease Inherited Human Transmissible Spongiform Encephalopathies Prion Protein Diseases Prion-Associated Disorders Prion-Induced Disorders Transmissible Dementias Tses Human Prion Disease Tse Encephalopathy, Transmissible Spongiform Prion Disease, Susceptibility To Spongiform Encephalopathies Human Transmissible Spongiform Encephalopathies, Inherited
Melanoma	Malignant Melanoma Cutaneous Melanoma Naevocarcinoma Malignant Melanomas
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (15)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-152860	Darizmetinib		99.94%	Unkown
HY-135699	TD52		95.0%	Unkown
HY-113592	ERK-IN-4	Inhibitor	98.30%	Unkown
HY-135699A	TD52 dihydrochloride		99.55%	Unkown
HY-RS04305	ELK1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W585976	Benzo[a]pyrene diol epoxide		/	Unkown
HY-111000	BNC-1		/	Unkown
HY-163323	AKR1C3-IN-12		/	Unkown
HY-P4133	MEK1 Derived Peptide Inhibitor 1	Inhibitor	/	Unkown
HY-RS07131	KCNH8 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-122241	MT477	Inhibitor	/	Unkown
HY-RS17329	Elk1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21611	Kcnh8 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23784	Elk1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28129	Kcnh8 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	ELK1	MGD	MGI:101833
Canis familiaris	ELK1	VGNC	VGNC:40303
Felis catus	ELK1	VGNC	VGNC:61810
Rattus norvegicus	ELK1	RGD	RGD:1598663
Bos taurus	ELK1	VGNC	VGNC:28432
Others	ELK1	NCBI