PRMT8 - protein arginine methyltransferase 8 Gene

Also Known as HRMT1L3; HRMT1L4

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 56341

About PRMT8

Cytogenetic location: 12p13.32 Genomic coordinates (GRCh38): 12:3,381,349-3,593,973 (from NCBI)

This gene has 4 transcripts (splice variants), 281 orthologues and 7 paralogues. Biased expression in brain (RPKM 5.7), testis (RPKM 0.8) and 1 other tissue.

Summary

Arginine methylation is a widespread posttranslational modification mediated by arginine methyltransferases, such as PRMT8. Arginine methylation is involved in a number of cellular processes, including DNA repair, RNA transcription, signal transduction, protein compartmentalization, and possibly protein translation (Lee et al., 2005 [PubMed 16051612]).[supplied by OMIM, Mar 2008]

PRMT8 Products (9)

mRNA Protein Name
NM_001256536.1 NP_001243465.1 protein arginine N-methyltransferase 8 isoform 2
XM_047429157.1 XP_047285113.1 protein arginine N-methyltransferase 8 isoform X3
XM_047429159.1 XP_047285115.1 protein arginine N-methyltransferase 8 isoform X5
XM_017019644.2 XP_016875133.1 protein arginine N-methyltransferase 8 isoform X1
XM_017019645.1 XP_016875134.1 protein arginine N-methyltransferase 8 isoform X2
XM_047429158.1 XP_047285114.1 protein arginine N-methyltransferase 8 isoform X4
NM_001256537.1
NR_046301.1
NM_019854.5 NP_062828.3 protein arginine N-methyltransferase 8 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables S-adenosyl-L-methionine binding IDA
IDA: Inferred from direct assay
26876602 GOA
enables S-adenosylmethionine-dependent methyltransferase activity IDA
IDA: Inferred from direct assay
16051612 GOA
enables enzyme binding IDA
IDA: Inferred from direct assay
16051612 GOA
enables histone H4 methyltransferase activity IDA
IDA: Inferred from direct assay
16051612 GOA
enables identical protein binding IDA
IDA: Inferred from direct assay
26876602 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16051612 GOA
enables protein homodimerization activity IPI
IPI: Inferred from physical interaction
16051612 GOA
enables protein-arginine omega-N asymmetric methyltransferase activity IDA
IDA: Inferred from direct assay
16051612 GOA
enables protein-arginine omega-N monomethyltransferase activity IDA
IDA: Inferred from direct assay
16051612 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in peptidyl-arginine methylation IDA
IDA: Inferred from direct assay
18320585 GOA
involved in protein homooligomerization IDA
IDA: Inferred from direct assay
26876602 GOA
involved in protein methylation IMP
IMP: Inferred from mutant phenotype
26876602 GOA
Cellular Component GO Annotation Evidence Verweise Source
located in cytoplasmic side of plasma membrane IDA
IDA: Inferred from direct assay
26876602 GOA
NOT located in nucleus IDA
IDA: Inferred from direct assay
16051612 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
16051612 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PRMT8 Protein Structure

PrmA

PrmA: Ribosomal protein L11 methyltransferase (PrmA) (108 - 184)

  • 0
  • 100
  • 200
  • 300
  • 394 a.a.
Protein Preferred Names Protein Names

protein arginine N-methyltransferase 8

  • HMT1 hnRNP methyltransferase-like 3

  • arginine methyltransferase 8

  • heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 4

  • protein arginine N-methyltransferase 4

PRMT8 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
PRMT8 Q9NR22 SYNCRIP Homo sapiens O60506
Y2H Array
19060904
Intra
PRMT8 Q9NR22 SYNCRIP Homo sapiens O60506
Y2H
23455924
Intra
PRMT8 Q9NR22 SYNCRIP Homo sapiens O60506
Anti Tag CoIP
33961781
Intra
PRMT8 Q9NR22 SYNCRIP Homo sapiens O60506
Y2H Pooling
19060904
Intra
PRMT8 Q9NR22 PRMT1 Homo sapiens Q99873-3
Y2H Array
32296183
Intra
PRMT8 Q9NR22 PRMT1 Homo sapiens Q99873-3
Y2H Prey Pooling
32296183
Intra
PRMT8 Q9NR22 PRMT1 Homo sapiens Q99873-3
MAPPIT
32296183
Intra
PRMT8 Q9NR22 PRMT8 Homo sapiens Q9NR22
Y2H
23455924
Intra
PRMT8 Q9NR22 PRMT8 Homo sapiens Q9NR22
Y2H Pooling
16189514
Intra
PRMT8 Q9NR22 PRMT8 Homo sapiens Q9NR22
Y2H Prey Pooling
32296183
Intra
PRMT8 Q9NR22 PRMT8 Homo sapiens Q9NR22
Y2H Array
19060904
Intra
PRMT8 Q9NR22 PRMT8 Homo sapiens Q9NR22
Validated Y2H
32296183
Intra
PRMT8 Q9NR22 PRMT8 Homo sapiens Q9NR22
Y2H Pooling
19060904
Intra
PRMT8 Q9NR22 PRMT8 Homo sapiens Q9NR22
Y2H Array
32296183
Intra
PRMT8 Q9NR22 PRMT1 Homo sapiens Q99873
Y2H
23455924
Intra
PRMT8 Q9NR22 PRMT1 Homo sapiens Q99873
Anti Tag CoIP
33961781
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Art. -Nr. Produktname Wirkung
Reinheit Phase
HY-128717 GSK3368715 Inhibitor 99.41% Phase 1

Pre-clinical Phase

Bioactive Molecules (12)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-19615 MS023 Inhibitor 99.93% Unkown
HY-128717A GSK3368715 dihydrochloride Inhibitor 99.96% Unkown
HY-19615B MS023 dihydrochloride Inhibitor 99.68% Unkown
HY-141877 MS4322 Degrader 99.14% Unkown
HY-100360 MS049 Inhibitor 98.0% Unkown
HY-141877B MS4322 (isomer) 99.87% Unkown
HY-128717B GSK3368715 trihydrochloride Inhibitor / Unkown
HY-161334 CARM1-IN-4 Inhibitor / Unkown
HY-184653 MS3-123 Inhibitor / Unkown
HY-186045 SKLB06489 Inhibitor / Unkown
HY-146810 PRMT4-IN-1 Inhibitor / Unkown
HY-175821 PRMT1-IN-3 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus PRMT8 RGD RGD:1587677
Mus musculus PRMT8 MGD MGI:3043083
Felis catus PRMT8 VGNC VGNC:67652
Bos taurus PRMT8 VGNC VGNC:33353
Canis familiaris PRMT8 VGNC VGNC:45001
Macaca mulatta PRMT8 VGNC VGNC:76360
Others PRMT8 NCBI