NANOG - Nanog homeobox Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 79923

About NANOG

Cytogenetic location: 12p13.31 Genomic coordinates (GRCh38): 12:7,789,402-7,799,146 (from NCBI)

This gene has 4 transcripts (splice variants), 233 orthologues and 9 paralogues. Low expression observed in reference dataset.

Summary

The protein encoded by this gene is a DNA binding homeobox transcription factor involved in embryonic stem (ES) cell proliferation, renewal, and pluripotency. The encoded protein can block ES cell differentiation and can also autorepress its own expression in differentiating cells. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]

NANOG Products (2)

mRNA	Protein	Name
NM_001297698.2	NP_001284627.1	homeobox protein NANOG isoform 2
NM_024865.4	NP_079141.2	homeobox protein NANOG isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables DNA binding	IDA IDA: Inferred from direct assay	16153702	GOA
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	16153702	GOA
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	23708658	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	26687479	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	25825768	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
involved in cell differentiation	IEP IEP: Inferred from expression pattern	16501172	GOA
acts upstream of or within endodermal cell fate specification	IDA IDA: Inferred from direct assay	20713518	GOA
involved in positive regulation of stem cell proliferation	IMP IMP: Inferred from mutant phenotype	16501172	GOA
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	20713518	GOA
involved in regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	16153702	GOA
involved in regulation of cell differentiation	IMP IMP: Inferred from mutant phenotype	16501172	GOA
involved in regulation of gene expression	IMP IMP: Inferred from mutant phenotype	18388306	GOA
involved in somatic stem cell population maintenance	IMP IMP: Inferred from mutant phenotype	18388306	GOA
involved in stem cell population maintenance	IEP IEP: Inferred from expression pattern	15108323	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
located in nucleolus	IDA IDA: Inferred from direct assay	20458727	GOA
located in nucleus	IDA IDA: Inferred from direct assay	18932205	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NANOG Protein Structure

Homeobox

0
100
200
305 a.a.

Protein Preferred Names	Protein Names
homeobox protein NANOG	homeobox transcription factor Nanog

Recombinant NANOG Proteins

Art. -Nr.	Produktname	Accession	Reinheit
HY-P7391	NANOG Protein, Human (His-SUMO)	Q9H9S0-1 (M1-V305)	≥ 90%, as determined by reducing SDS-PAGE.

NANOG Antibodies

Art. -Nr.	Produktname	Anwendung	Reactivity
HY-P80237	Nanog Antibody (YA275)	WB, ICC/IF, FC, IHC-P	Human, Mouse
HY-P84804	Nanog Antibody (YA4501)	WB, ICC/IF, ELISA	Human
HY-P84804A	Nanog Antibody (YA4501)(PBS only)	WB, ICC/IF, ELISA	Human
HY-P85292	Nanog Antibody (YA4984)	WB; IHC-P; IHC-F; ICC/IF; IF-Tissue	Human, Mouse, Rat
HY-P86599	Nanog Antibody (YA6291)	WB, IHC-P, ICC/IF, IP, ELISA	Human

Related Diseases

Diseases	Alias
Teratocarcinoma	Mixed Embryonal Carcinoma And Teratoma
Germ Cell And Embryonal Cancer	Germ Cell And Embryonal Neoplasm
Embryonal Carcinoma	Embryonal Neoplasm Embryonal Cancer Primary Extragonadal Embryonal Carcinoma Embryo Neoplasm Carcinoma Embryonal Cancer Embryonal Carcinoma, Embryonal Extragonadal Embryonal Carcinoma Cancer, Embryonal
Cystadenocarcinoma
Seminoma	Seminoma, Pure
Tyrosinemia	Hypertyrosinemia Tyrosinemias Hereditary Tyrosinemia Hypertyrosinaemia Tyrosinaemia Hereditary Hypertyrosinemia
Germ Cell Cancer	Malignant Germ Cell Tumor Neoplasms, Germ Cell And Embryonal Germ Cell Neoplasm Germ Cell Tumour Malignant Tumor Of The Germ Cell Neoplasms Germ Cell Malignant Germ Cell Neoplasm
Mature Teratoma	Dermoid Cyst Benign Teratoma
Malignant Teratoma	Immature Teratoma Malignant Extragonadal Teratoma Primary Malignant Extragonadal Teratoma Teratoma, Malignant, Nos Teratoma, Malignant Immature Extragonadal Teratoma
Hepatocellular Carcinoma	Liver Cancer Primary Liver Cancer HCC Hepatoma Malignant Neoplasm Of Liver Liver Neoplasms Cancer, Hepatocellular Liver Cell Carcinoma Lcc Hepatoblastoma, Somatic Hepatic Cancer Primary Malignant Neoplasm Of Liver Rare Tumor Of Liver And Intrahepatic Biliary Tract Hepatocellular Carcinoma, Somatic Hepatocellular Carcinoma, Childhood Type, Somatic Hepatocellular Cancer, Somatic Ca Liver - Primary Hepatic Neoplasm Malignant Hepato-Biliary Neoplasm Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary Malignant Neoplasm Of Liver, Primary Malignant Tumor Of Liver Neoplasm Of Liver Non-Resectable Primary Hepatic Malignant Neoplasm Resectable Malignant Neoplasm Of Liver Resectable Malignant Neoplasm Of The Liver Primary Liver Carcinoma Primary Malignant Liver Neoplasm Primary Cancer Of Liver Primary Tumor Of The Liver Rare Tumor Of Liver And Ibt Hepatocellular Cancer Neoplasm Of The Liver Carcinoma, Hepatocellular Hepatomas Liver Neoplasm Liver Carcinoma Liver And Intrahepatic Biliary Tract Carcinoma Malignant Hepatobiliary Neoplasm Adult Primary Hepatocellular Carcinoma Hepatoblastoma Carcinoma Of Liver Malignant Liver Tumour Malignant Hepatic Tumour
Mixed Germ Cell Cancer	Mixed Germ Cell Tumor Mixed Germ Cell Neoplasm Mixed Germ Cell Tumour Mixed Teratoma And Seminoma
Glycogen Storage Disease	Glycogenosis Glycogenoses Gsd Storage Disease, Glycogen Gsd - [Glycogen Storage Disease] Glycogen Thesaurismosis Diffuse Glycogenosis Generalised Glycogen Storage Disease Generalised Glycogenosis Generalised Glycogen Storage Disease Of Infants Glycogen Synthase Deficiency
Brain Germinoma	Intracranial Germinoma Germinoma Of The Brain
Dysgerminoma Of Ovary	Ovarian Dysgerminoma Malignant Dysgerminomatous Germ Cell Tumour Of Ovary Dysgerminoma, Unspecified Site, Female
Duane-Radial Ray Syndrome	Okihiro Syndrome DRRS Dr Syndrome Duane Anomaly With Radial Ray Abnormalities And Deafness Acrorenoocular Syndrome Acrorenocular Syndrome Duane Anomaly With Radial Abnormalities And Deafness Acro-Renal-Ocular Syndrome
Spermatocytoma	Spermatocytic Seminoma
Macular Degeneration, Age-Related, 7	Age Related Macular Degeneration 7 ARMD7 Macular Degeneration, Age-Related, Neovascular Type Susceptibility To Neovascular Type Of Age-Related Macular Degeneration Macular Degeneration, Age-Related, Type 7
Medulloblastoma	MDB Cpnet Localized Primitive Neuroectodermal Tumor Classic Medulloblastoma Medulloblastoma Predisposition Syndrome Medulloblastoma, Somatic Brain Medulloblastoma Cns Pnet Infratentorial Primitive Neuroectodermal Tumor Neuroectodermal Tumors, Primitive Medulloblastomas Desmoplastic Medulloblastoma Medulloblastoma, With Extensive Nodularity Medulloblastoma Of Unspecified Site Medullomyoblastoma Of Unspecified Site
Glioblastoma Classical Subtype
Testicular Disease	Testicular Dysfunction Testicular Diseases Disorder Of Testis Testis Disorder Testicular Disorders
Ovarian Cancer	Ovarian Carcinoma Ovarian Neoplasm Malignant Tumour Of Ovary Cancer Of The Ovary Epithelial Ovarian Cancer Neoplasm Of Ovary Ovarian Neoplasms Ovarian Cancers Malignant Neoplasm Of Ovary Primary Malignant Neoplasm Of Ovary Ovarian Cancer, Somatic Malignant Ovarian Tumor Ovary Neoplasm Primary Ovarian Cancer Tumor Of The Ovary Malignant Neoplasm Of The Ovary Malignant Tumor Of The Ovary Ovarian Malignant Tumor OC Ovarian Carcinomas Cancer, Ovarian Cancer Of Ovary Ovary Cancer Ca Ovary
Parkinson Disease 17	PARK17 Parkinson'S Disease 17 Autosomal Dominant Parkinson Disease 17 Parkinson Disease, Type 17
Testicular Cancer	Testis Cancer Testicular Carcinoma Testicular Neoplasms Malignant Neoplasm Of Testis Childhood Neoplasm Of The Testis Neoplasm Of Testis Pediatric Testicular Neoplasm Testicular Tumor Testis Neoplasm Testicular Tumors Testicular Neoplasm Testicular Malignant Germ Cell Tumor Childhood Testicular Neoplasm Carcinoma Of The Testis Cancer Of Testis Malignant Neoplasm Of Testis, Nos Malignant Neoplasm Of Testis, Unspecified Malignant Tumour Of Testis Testicle Cancer Primary Malignant Neoplasm Of Testis
Severe Combined Immunodeficiency	Scid Severe Combined Immunodeficiency Disease Combined T And B Cell Inborn Immunodeficiency Immunodeficiency, Severe Combined Scid - [Severe Combined Immunodeficiencies]
Leukemia, Acute Myeloid	Acute Myeloid Leukemia Leukemia, Acute Myelogenous Acute Myelogenous Leukemia AML Leukemia, Acute Myeloid, Susceptibility To Acute Myeloblastic Leukemia Leukemia, Acute Myeloid, Reduced Survival In, Somatic Acute Myeloid Leukaemia Leukemia, Myelocytic, Acute Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome Secondary Aml Acute Myelocytic Leukemia Acute Myeloid Leukemia, Somatic Leukemia, Acute Myeloid, Somatic Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic Acute Myeloblastic Leukaemia Acute Myelogenous Leukaemia Aml - Acute Myeloid Leukemia Acute Myeloid Leukemia With Cebpa Somatic Mutations Aml With Cebpa Somatic Mutations Inherited Acute Myeloid Leukemia Familial Aml Inherited Aml Pure Familial Aml Pure Familial Acute Myeloid Leukemia Secondary Acute Myeloid Leukemia Therapy-Related Aml And Myelodysplastic Syndrome Acute Myeloid Leukemia, Secondary Acute Non-Lymphoblastic Leukemia Acute Non-Lymphocytic Leukemia Acute Biphenotypic Leukemia Acute Undifferentiated Leukemia Acute Myeloblastic Leukaemia With Multilineage Dysplasia Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission Acute Myeloid Leukaemia With Myelodysplasia-Related Features
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder
Retinitis Pigmentosa	RP Rod-Cone Dystrophy Autosomal Recessive Retinitis Pigmentosa Non-Syndromic Retinitis Pigmentosa Pericentral Pigmentary Retinopathy Pigmentary Retinopathy Tapetoretinal Degeneration Rcd Retinitis Pigmentosa Autosomal Recessive ARRP Retinitis Pigmentosa, Autosomal Recessive Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (2)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-B0356A	Ciprofloxacin monohydrochloride		99.86%	Unkown
HY-B0356B	Ciprofloxacin hydrochloride monohydrate		99.88%	Yes

Clinical Phase

Bioactive Molecules (1)

Art. -Nr.	Produktname	Wirkung	Reinheit	Phase
HY-17602	Amcasertib	Inducer	98.03%	Phase 2

Pre-clinical Phase

Bioactive Molecules (16)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-12303	OAC1	Activator	99.85%	Unkown
HY-18772	O4I2		99.18%	Unkown
HY-18771	O4I1	Activator	98.05%	Unkown
HY-119672	Oct4 inducer-1	Activator	99.92%	Unkown
HY-10321G	PD173074 (GMP)	Inhibitor	/	Unkown
HY-129108	9-cis-UAB30		/	Unkown
HY-168566	EV206	Inhibitor	99.62%	Unkown
HY-168885	ZSH-512		/	Unkown
HY-179339	LSD1-IN-46	Inhibitor	/	Unkown
HY-B0356G	Ciprofloxacin (GMP)		/	Unkown
HY-RS09019	NANOG Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-119666	Rooperol	Activator	/	Unkown
HY-174574	Human NANOG mRNA		/	Unkown
HY-N15201	Betavulgarin	Inhibitor	/	Unkown
HY-RS19720	Nanog Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26216	Nanog Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	NANOG	RGD	RGD:1303178
Mus musculus	NANOG	MGD	MGI:1919200