RAMAC - RNA guanine-7 methyltransferase activating subunit Gene

Also Known as RAM; RAMMET; C15orf18; FAM103A1; HsT19360

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 83640

About RAMAC

Cytogenetic location: 15q25.2 Genomic coordinates (GRCh38): 15:82,986,210-82,991,057 (from NCBI)

This gene has 1 transcript (splice variant), 187 orthologues and 1 paralogue. Ubiquitous expression in placenta (RPKM 19.2), colon (RPKM 16.4) and 25 other tissues.

Summary

Enables RNA binding activity and enzyme activator activity. Involved in methylation and recruitment of mRNA capping enzyme to RNA polymerase II holoenzyme complex. Located in nucleoplasm. Part of mRNA cap binding activity complex and mRNA cap methyltransferase complex. [provided by Alliance of Genome Resources, Apr 2022]

RAMAC Products (1)

mRNA Protein Name
NM_031452.4 NP_113640.1 RNA guanine-N7 methyltransferase activating subunit

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables RNA binding IDA
IDA: Inferred from direct assay
22099306 GOA
enables enzyme activator activity IDA
IDA: Inferred from direct assay
27422871 GOA
enables molecular function activator activity EXP
EXP: Inferred from Experiment
27422871 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
22099306 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in 7-methylguanosine mRNA capping IDA
IDA: Inferred from direct assay
22099306 GOA
Cellular Component GO Annotation Evidence Verweise Source
part of mRNA cap methyltransferase RNMT:RAMAC complex IDA
IDA: Inferred from direct assay
22099306 GOA
part of mRNA capping enzyme complex IDA
IDA: Inferred from direct assay
27422871 GOA
located in nucleus IDA
IDA: Inferred from direct assay
22099306 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RAMAC Protein Structure

RAM

RAM: mRNA cap methylation, RNMT-activating mini protein (10 - 89)

  • 0
  • 100
  • 118 a.a.
Protein Preferred Names Protein Names

RNA guanine-N7 methyltransferase activating subunit

  • RNMT activating mRNA cap methyltransferase subunit

RAMAC Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
RAMAC Q9BTL3 KRTAP8-1 Homo sapiens Q8IUC2
Y2H Prey Pooling
32296183
Intra
RAMAC Q9BTL3 KRTAP8-1 Homo sapiens Q8IUC2
Y2H Array
32296183
Intra
RAMAC Q9BTL3 KRT33B Homo sapiens Q14525
Y2H Prey Pooling
32296183
Intra
RAMAC Q9BTL3 KRT33B Homo sapiens Q14525
Y2H Array
32296183
Intra
RAMAC Q9BTL3 KRTAP1-3 Homo sapiens Q8IUG1
Y2H Prey Pooling
32296183
Intra
RAMAC Q9BTL3 KRTAP1-3 Homo sapiens Q8IUG1
Y2H Array
32296183
Intra
RAMAC Q9BTL3 USP54 Homo sapiens Q70EL1-9
Y2H Prey Pooling
32296183
Intra
RAMAC Q9BTL3 USP54 Homo sapiens Q70EL1-9
Y2H Array
32296183
Intra
RAMAC Q9BTL3 FOXI1 Homo sapiens Q12951-2
Y2H Array
32296183
Intra
RAMAC Q9BTL3 FOXI1 Homo sapiens Q12951-2
Y2H Prey Pooling
32296183
Intra
RAMAC Q9BTL3 WWOX Homo sapiens Q9NZC7-5
Y2H Array
32296183
Intra
RAMAC Q9BTL3 WWOX Homo sapiens Q9NZC7-5
Y2H Prey Pooling
32296183
Intra
RAMAC Q9BTL3 WWOX Homo sapiens Q9NZC7-5
Validated Y2H
32296183
Intra
RAMAC Q9BTL3 FAM168B Homo sapiens A1KXE4-2
Y2H Prey Pooling
32296183
Intra
RAMAC Q9BTL3 FAM168B Homo sapiens A1KXE4-2
Y2H Array
32296183
Intra
RAMAC Q9BTL3 C10orf55 Homo sapiens Q5SWW7
Y2H Array
32296183
Intra
RAMAC Q9BTL3 C10orf55 Homo sapiens Q5SWW7
Y2H Prey Pooling
32296183
Intra
RAMAC Q9BTL3 OXER1 Homo sapiens Q8TDS5
Y2H Prey Pooling
32296183
Intra
RAMAC Q9BTL3 OXER1 Homo sapiens Q8TDS5
Y2H Array
32296183
Intra
RAMAC Q9BTL3 NAF1 Homo sapiens Q96HR8
Y2H Array
32296183
Intra
RAMAC Q9BTL3 NAF1 Homo sapiens Q96HR8
Y2H Prey Pooling
32296183
Intra
RAMAC Q9BTL3 VPS37C Homo sapiens A5D8V6
Y2H Prey Pooling
32296183
Intra
RAMAC Q9BTL3 VPS37C Homo sapiens A5D8V6
Y2H Array
32296183
Intra
RAMAC Q9BTL3 PRR3 Homo sapiens P79522
Y2H Array
32296183
Intra
RAMAC Q9BTL3 PRR3 Homo sapiens P79522
Y2H Prey Pooling
32296183
Intra
RAMAC Q9BTL3 BAG4 Homo sapiens O95429
Y2H Prey Pooling
32296183
Intra
RAMAC Q9BTL3 BAG4 Homo sapiens O95429
Y2H Array
32296183
Intra
RAMAC Q9BTL3 PSMA3 Homo sapiens P25788
Validated Y2H
25416956
Intra
RAMAC Q9BTL3 PSMA3 Homo sapiens P25788
Y2H Array
25416956
Intra
RAMAC Q9BTL3 SF3B4 Homo sapiens Q15427
Y2H Prey Pooling
32296183
Intra
RAMAC Q9BTL3 SF3B4 Homo sapiens Q15427
Y2H Array
32296183
Intra
RAMAC Q9BTL3 HNRNPH1 Homo sapiens P31943
Y2H Prey Pooling
32296183
Intra
RAMAC Q9BTL3 HNRNPH1 Homo sapiens P31943
Y2H Array
32296183
Intra
RAMAC Q9BTL3 AKAP8L Homo sapiens Q9ULX6
Y2H Array
32296183
Intra
RAMAC Q9BTL3 AKAP8L Homo sapiens Q9ULX6
Validated Y2H
32296183
Intra
RAMAC Q9BTL3 AKAP8L Homo sapiens Q9ULX6
Y2H Prey Pooling
32296183
Intra
RAMAC Q9BTL3 CYSRT1 Homo sapiens A8MQ03
Y2H Prey Pooling
32296183
Intra
RAMAC Q9BTL3 CYSRT1 Homo sapiens A8MQ03
Y2H Array
32296183
Intra
RAMAC Q9BTL3 TRIM42 Homo sapiens Q8IWZ5
Validated Y2H
25416956
Intra
RAMAC Q9BTL3 GOLGA2 Homo sapiens Q08379
Y2H Prey Pooling
32296183
Intra
RAMAC Q9BTL3 GOLGA2 Homo sapiens Q08379
Y2H Array
32296183
Intra
RAMAC Q9BTL3 INCA1 Homo sapiens Q0VD86
Y2H Prey Pooling
32296183
Intra
RAMAC Q9BTL3 INCA1 Homo sapiens Q0VD86
Y2H Array
25416956
Intra
RAMAC Q9BTL3 INCA1 Homo sapiens Q0VD86
Y2H Array
32296183
Intra
RAMAC Q9BTL3 HNRNPK Homo sapiens P61978-2
Y2H Array
32296183
Intra
RAMAC Q9BTL3 HNRNPK Homo sapiens P61978-2
Y2H Prey Pooling
32296183
Intra
RAMAC Q9BTL3 MAGED1 Homo sapiens Q9Y5V3
Validated Y2H
32296183
Intra
RAMAC Q9BTL3 MAGED1 Homo sapiens Q9Y5V3
Y2H Array
32296183
Intra
RAMAC Q9BTL3 MAGED1 Homo sapiens Q9Y5V3
Y2H Prey Pooling
32296183
Intra
RAMAC Q9BTL3 TRIM27 Homo sapiens P14373
Y2H Array
25416956
Intra
RAMAC Q9BTL3 TRIM27 Homo sapiens P14373
Y2H Prey Pooling
25416956
Intra
RAMAC Q9BTL3 TRIM27 Homo sapiens P14373
Validated Y2H
25416956
Intra
RAMAC Q9BTL3 DAZAP2 Homo sapiens Q15038
Y2H Prey Pooling
32296183
Intra
RAMAC Q9BTL3 DAZAP2 Homo sapiens Q15038
Y2H Array
32296183
Intra
RAMAC Q9BTL3 RINT1 Homo sapiens Q6NUQ1
Y2H Prey Pooling
32296183
Intra
RAMAC Q9BTL3 RINT1 Homo sapiens Q6NUQ1
Y2H Array
32296183
Intra
RAMAC Q9BTL3 KRT15 Homo sapiens P19012
Y2H Array
32296183
Intra
RAMAC Q9BTL3 KRT15 Homo sapiens P19012
Y2H Prey Pooling
32296183
Intra
RAMAC Q9BTL3 TRIM23 Homo sapiens P36406
Y2H Prey Pooling
25416956
Intra
RAMAC Q9BTL3 TRIM23 Homo sapiens P36406
Y2H Prey Pooling
32296183
Intra
RAMAC Q9BTL3 TRIM23 Homo sapiens P36406
Y2H Array
32296183
Intra
RAMAC Q9BTL3 LZTS2 Homo sapiens Q9BRK4
Validated Y2H
25416956
Intra
RAMAC Q9BTL3 MAPK1IP1L Homo sapiens Q8NDC0
Y2H Prey Pooling
32296183
Intra
RAMAC Q9BTL3 MAPK1IP1L Homo sapiens Q8NDC0
Y2H Array
32296183
Intra
RAMAC Q9BTL3 TEKT4 Homo sapiens Q8WW24
Y2H Prey Pooling
32296183
Intra
RAMAC Q9BTL3 TEKT4 Homo sapiens Q8WW24
Y2H Array
32296183
Intra
RAMAC Q9BTL3 PLSCR4 Homo sapiens Q9NRQ2
Validated Y2H
32296183
Intra
RAMAC Q9BTL3 DAB1 Homo sapiens O75553
Validated Y2H
25416956
Intra
RAMAC Q9BTL3 DAB1 Homo sapiens O75553
Y2H Array
25416956
Intra
RAMAC Q9BTL3 RBMY1F Homo sapiens Q15415
Y2H Prey Pooling
25416956
Intra
RAMAC Q9BTL3 RBMY1F Homo sapiens Q15415
Y2H Array
25416956
Intra
RAMAC Q9BTL3 RBMY1F Homo sapiens Q15415
Validated Y2H
25416956
Intra
RAMAC Q9BTL3 TEKT3 Homo sapiens Q9BXF9
Validated Y2H
32296183
Intra
RAMAC Q9BTL3 TEKT3 Homo sapiens Q9BXF9
Y2H Array
32296183
Intra
RAMAC Q9BTL3 TEKT3 Homo sapiens Q9BXF9
Y2H Prey Pooling
32296183
Intra
RAMAC Q9BTL3 RNMT Homo sapiens O43148
Anti Tag CoIP
33961781
Intra
RAMAC Q9BTL3 RNMT Homo sapiens O43148
Y2H Prey Pooling
32296183
Intra
RAMAC Q9BTL3 RNMT Homo sapiens O43148
Y2H Array
32296183
Intra
RAMAC Q9BTL3 POU2AF1 Homo sapiens Q16633
Y2H Array
32296183
Intra
RAMAC Q9BTL3 POU2AF1 Homo sapiens Q16633
Y2H Prey Pooling
32296183
Intra
RAMAC Q9BTL3 KRT31 Homo sapiens Q15323
Validated Y2H
25416956
Intra
RAMAC Q9BTL3 KRT31 Homo sapiens Q15323
Y2H Prey Pooling
32296183
Intra
RAMAC Q9BTL3 KRT31 Homo sapiens Q15323
Y2H Array
25416956
Intra
RAMAC Q9BTL3 KRT31 Homo sapiens Q15323
Y2H Array
32296183
Intra
RAMAC Q9BTL3 KRT31 Homo sapiens Q15323
Y2H Prey Pooling
25416956
Intra
RAMAC Q9BTL3 TNS2 Homo sapiens Q63HR2
Y2H Prey Pooling
32296183
Intra
RAMAC Q9BTL3 TNS2 Homo sapiens Q63HR2
Y2H Array
32296183
Intra
RAMAC Q9BTL3 BPIFA1 Homo sapiens Q9NP55
Y2H Array
32296183
Intra
RAMAC Q9BTL3 BPIFA1 Homo sapiens Q9NP55
Validated Y2H
32296183
Intra
RAMAC Q9BTL3 BPIFA1 Homo sapiens Q9NP55
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Murray Valley Encephalitis

  • Australian Encephalitis

  • Australian X Disease

  • Encephalitis Australia

  • Murray River Encephalitis

  • Australian Arboencephalitis

  • Australian X Disorder

  • Mve - [Murray Valley Encephalitis]
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS11637 RAMAC Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus RAMAC MGD MGI:1914398
Rattus norvegicus RAMAC RGD RGD:1310022
Bos taurus RAMAC VGNC VGNC:55894
Canis familiaris RAMAC VGNC VGNC:53171
Others RAMAC NCBI