Germicidin B
Germicidin B is an antibiotic with bactericidal activity. Germicidin B inhibits hexokinase II with an IC50 of 25.16 μM. Germicidin B suppresses spore germination in Streptomyces. Germicidin B is applicable to studies on bacterial infections.
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- CAS. Nr.: 150973-78-7
- Formel: C10H14O3
- Molecular Weight:182.22
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Help & FAQs
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Biologische Aktivität
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hexokinase II 25.16 μM (IC50) |
Germicidin B (37 °C, 10 min) significantly inhibits the activity of purified hexokinase II, with an IC50 of 7.11 μM[1].
Germicidin B (0.01-1000 μg/mL) inhibits spore germination of Streptomyces [3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 150973-78-7
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Molecular Weight 182.22
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Formel C10H14O3
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SMILES
O=C1OC(C(C)C)=CC(O)=C1CC
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Structure Classification
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Initial Source
Streptomyces Viridochromogenes
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
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Data Sheet (270 KB)
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SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Aoki Y, Matsumoto D, Kawaide H, Natsume M. Physiological role of germicidins in spore germination and hyphal elongation in Streptomyces coelicolor A3(2). J Antibiot (Tokyo). 2011 Sep;64(9):607-11. [Content Brief]
[2]. Zhang XM, et al. Hexokinase II Inhibitory Effect of Secondary Metabolites Derived from a Streptomyces sp. Associated with Mud Dauber Wasp. Chem Biodivers. 2020;17(7):e2000140. [Content Brief]
[3]. Song L, et al. Type III polyketide synthase beta-ketoacyl-ACP starter unit and ethylmalonyl-CoA extender unit selectivity discovered by Streptomyces coelicolor genome mining. J Am Chem Soc. 2006;128(46):14754-14755. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Germicidin B Related Classifications
HY-111331 Related Classifications
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