HDMAPP triammonium
Based on 1 Customer Validation
HDMAPP triammonium is a potent phosphoantigen in the ammonium form and the pyrophosphate form of (E)-HDMAPP. HDMAPP is also a potent activator of γδ T cells and can induce T cell stimulation in vitro (EC50=0.39 nM, TNF-α).
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- Reinheit : 90.0%
- CAS. Nr.: 443892-56-6
- Formel: C5H21N3O8P2
- Molecular Weight:313.18
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Speicherung:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Protokoll
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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Biologische Aktivität
Beschreibung
IC50 & Target
[1]|
TNFRSF1A |
In Vitro
HDMAPP triammonium (compound 3E) (2 μM) increases TNF-α release levels in primary polyclonal human Vγ9Vδ2 T cells and has stimulatory bioactivity[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Nonhuman Primate Model in Cynomolgus[1]
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Dosage:0.02 mg/kg, 0.1 mg/kg, 0.5 mg/kg, 2.5 mg/kg
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Administration:Intravenous injection; once with daily s.c. low doses IL-2 to sustain γδ-T-cell proliferation, for 15 days
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Result:Significantly increased γδ-cells in vivo at 0.02 mg/kg. Reached maximal effect at 2.5 mg/kg.
Chemical Information
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CAS. Nr. 443892-56-6
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Appearance Solid
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Molecular Weight 313.18
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Formel C5H21N3O8P2
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Color White to off-white
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SMILES
OC/C(C)=C/COP(OP(O)(O)=O)(O)=O.N.N.N
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Lösungsmittel & Löslichkeit
In Vitro:
PBS : 10 mg/mL (31.93 mM; ultrasonic and warming and adjust pH to 7.2)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (271 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| PBS | 1 mM | 3.1931 mL | 15.9653 mL | 31.9305 mL | 79.8263 mL |
| 5 mM | 0.6386 mL | 3.1931 mL | 6.3861 mL | 15.9653 mL | |
| 10 mM | 0.3193 mL | 1.5965 mL | 3.1931 mL | 7.9826 mL | |
| 15 mM | 0.2129 mL | 1.0644 mL | 2.1287 mL | 5.3218 mL | |
| 20 mM | 0.1597 mL | 0.7983 mL | 1.5965 mL | 3.9913 mL | |
| 25 mM | 0.1277 mL | 0.6386 mL | 1.2772 mL | 3.1931 mL | |
| 30 mM | 0.1064 mL | 0.5322 mL | 1.0644 mL | 2.6609 mL |
HDMAPP triammonium Related Classifications
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