HEMADO
Based on 1 Customer Validation
HEMADO is a potent and selective adenosine A3 receptor agonist with a Ki of 1.1 nM at the human A3 subtype. HEMADO is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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- Reinheit: 99.0%
- CAS. Nr.: 403842-38-6
- Formel: C17H23N5O4
- Molecular Weight:361.40
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Speicherung:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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Biologische Aktivität
Ki: 1.1 nM (human A3 subtype)[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CHO | EC50 |
100 μM
Compound: 8a
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Receptor-stimulated activity in CHO cells stably transfected with Human recombinant Adenosine A2B receptor using [3H]NECA as radioligand
Receptor-stimulated activity in CHO cells stably transfected with Human recombinant Adenosine A2B receptor using [3H]NECA as radioligand
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[PMID: 12109910] |
HEMADO (compound 8a) has Kis of 327 nM and 1230 nM for A1 and A2A and a EC50 of 100 μM for A2B receptors[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 403842-38-6
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Appearance Solid
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Molecular Weight 361.40
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Formel C17H23N5O4
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Color White to off-white
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SMILES
OC[C@@H]1[C@H]([C@H]([C@H](N2C=NC3=C2N=C(C#CCCCC)N=C3NC)O1)O)O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Lösungsmittel & Löslichkeit
DMSO : 20 mg/mL (55.34 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (272 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Klotz KN, et al. [3H]HEMADO— a novel tritiated agonist selective for the human adenosine A3 receptor. Eur J Pharmacol. 2007 Feb 5;556(1-3):14-8. Epub 2006 Oct 27. [Content Brief]
[2]. Volpini R, et al. N(6)-alkyl-2-alkynyl derivatives of adenosine as potent and selective agonists at the human adenosine A(3) receptor and a starting point for searching A(2B) ligands. J Med Chem. 2002 Jul 18;45(15):3271-9. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.7670 mL | 13.8351 mL | 27.6702 mL | 69.1754 mL |
| 5 mM | 0.5534 mL | 2.7670 mL | 5.5340 mL | 13.8351 mL | |
| 10 mM | 0.2767 mL | 1.3835 mL | 2.7670 mL | 6.9175 mL | |
| 15 mM | 0.1845 mL | 0.9223 mL | 1.8447 mL | 4.6117 mL | |
| 20 mM | 0.1384 mL | 0.6918 mL | 1.3835 mL | 3.4588 mL | |
| 25 mM | 0.1107 mL | 0.5534 mL | 1.1068 mL | 2.7670 mL | |
| 30 mM | 0.0922 mL | 0.4612 mL | 0.9223 mL | 2.3058 mL | |
| 40 mM | 0.0692 mL | 0.3459 mL | 0.6918 mL | 1.7294 mL | |
| 50 mM | 0.0553 mL | 0.2767 mL | 0.5534 mL | 1.3835 mL |
HEMADO Related Classifications
HY-103187 Related Classifications
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