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Art. -Nr.: HY-P992004

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KHK2805

Name: KHK2805
Brand: MedChemExpress
SKU: HY-P992004
Availability: PreOrder

(Synonyms: RA15-7, HuRA15-7Acc)

KHK2805 (RA15-7) is a humanized antibody against folate receptor α (FOLR1), with a K_d of 0.647 nM for human FOLR1. KHK2805 binds to a unique epitope of FOLR1 and mediates antibody-dependent cellular cytotoxicity and complement-dependent cytotoxicity against FOLR1-expressing cells. KHK2805 exhibits cytotoxicity against both ovarian cancer cells and Platinum (HY-W096169D)-resistant ovarian cancer cells. KHK2805 can be used for the research of tumors such as ovarian cancer.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

KHK2805 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Species Reactivity
- In Vitro
- In Vivo
- Gene ID
- Accession
- Target
- Conjugated
- Reconsititution
- Format
- Anwendung
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Species Reactivity

Human

Alle Folate Receptor (FR) Isoform-spezifische Produkte anzeigen :

FR-α

In Vitro

KHK2805 (10 μg/mL; 1 h) binds strongly to the FOLR1-expressing human ovarian cancer cell lines IGROV1, OVMANA, SKOV3 and OVCAR3^[1].
KHK2805 (0.1-10000 ng/mL; 2 h) induces complement-dependent cytotoxicity (CDC) against FOLR1-expressing human ovarian cancer cell lines IGROV1 and OVMANA^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

KHK2805 (0.1-10 mg/kg; i.v.; twice/once a week) significantly reduces intraperitoneal tumor burden and ascites volume in SCID mice with peritoneal dissemination of Platinum (HY-W096169D)-resistant ovarian cancer^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

SCID mice (C.B-17/Icr-scid/scid Jcl, female, 6 weeks old, Platinum (HY-W096169D)-resistant peritoneal dissemination and malignant ascites model induced by intraperitoneal inoculation of IGROV1 cells)^[1]
Dosage:

0.1 mg/kg; 1 mg/kg; 10 mg/kg
Administration:

i.v.; twice a week; once a week
Result:

Significantly reduced intraperitoneal tumor burden and eliminated detectable malignant ascites (10 mg/kg, twice a week).
Significantly reduced both intraperitoneal tumor burden and ascites volume (1 mg/kg, once a week).
Reduced tumor burden and ascites volume, with no statistically significant effects (0.1 mg/kg, once a week).
Significantly prolonged median survival.

Gene ID

2348 [NCBI]

Accession

P15328

Target

FOLR1/FRA

Conjugated

Unconjugated

Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.

Format

Product Image

Anwendung

ELISA, FACS, Functional assay

Chemical Information

SMILES

[KHK2805]
Synonyms

RA15-7, HuRA15-7Acc
Formulation

Please refer to the lot-specific COA for specific buffer information.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Inhibitory Antibodies User Guide (603 KB)

Verweise

[1]. Ando M, et al. Potent Therapeutic Activity Against Peritoneal Dissemination and Malignant Ascites by the Novel Anti-Folate Receptor Alpha Antibody KHK2805. Transl Oncol. 2017;10(5):707-718. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Biologische Aktivität
- Beschreibung
- Species Reactivity
- In Vitro
- In Vivo
- Gene ID
- Accession
- Target
- Conjugated
- Reconsititution
- Format
- Anwendung
Chemical Information
Reinheit & Dokumentation
Verweise

Produktname:
Art. -Nr.:
Menge:
MCE Japan Authorized Agent:

Produktname:
CAS. Nr.:
Species:
Reinheit:
Menge:

KHK2805

PBS Buffer (1×)

Cytotoxicity LDH Assay Kit

DPBS Buffer (1×)

Alle Folate Receptor (FR) Isoform-spezifische Produkte anzeigen