LS24-16
LS24-16 is a carbonic anhydrase (CA) IX enzyme inhibitor (Ki ≤ 1.6 nM versus human CA IX; Kd = 0.40 nM). LS24-16 inhibits carbon dioxide hydration by binding to the catalytic zinc site and displacing the zinc-bound water with its deprotonated sulfamate amino group. LS24-16 competes with fluorescent CA IX probes for binding to CA IX on hypoxic cells and remains stable under the tested stress conditions. LS24-16 can be used for solid tumor research.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- CAS. Nr.: 2352790-85-1
- Formel: C13H13NO4S
- Molecular Weight:279.31
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Biologische Aktivität
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Chemical Information
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Help & FAQs
Biologische Aktivität
Beschreibung
IC50 & Target
[1]|
hCA IX 0.40 nM (Kd) |
CA VII 6.1 nM (Kd) |
CA XIII 6.2 nM (Kd) |
In Vitro
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 2352790-85-1
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Molecular Weight 279.31
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Formel C13H13NO4S
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SMILES
NS(OC1=CC=CC=C1OCC2=CC=CC=C2)(=O)=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
LS24-16 Related Classifications
HY-190902 Related Classifications
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