NCO-700
NCO-700 is a dual cathepsin B and calcium-activated neutral protease (CANP) inhibitor with IC50 values of 0.8 and 46 μM, respectively. NCO-700 reduces the degradation of myocardial fibrin by inhibiting protease activity. NCO-700 also has inhibitory effects on hormone-independent tumor cells, such as prostate cancer cells, and induces apoptosis. NCO-700 can be used to study myocardial ischemia and refractory hormone-independent tumors.
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- CAS. Nr.: 84518-80-9
- Formel: C26H39N3O8
- Molecular Weight:521.60
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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Biologische Aktivität
NCO-700 (7 days) inhibits HS-578T, PC-3, DU-145, MCF-7, LNCaP and T47D cells proliferation with IC50s of 7.5, 10, 11.5, 72 and >100 μM[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
NCO-700 (10-100 mg/kg, i.p., once daily for 5 days) demonstrates significant anti-tumor activity in xenograft models of prostate cancer and breast cancer in mice[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:
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Dosage:20 and 40 mg/kg (total dose)
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Administration:Intraperitoneal injection (i.p.), 4 administrations of medication
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Result:Reduced the infarcted area by 11.5% and 22.3% at 20 and 40 mg/kg in rabbit model.
Significantly inhibited the degradation of myofibrillar proteins induced by ischemia in dog model.
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Animal Model:Xenograft models of prostate cancer and breast cancer established in Balb/C mice[2]
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Dosage:10, 20 and 40 mg/kg (prostate cancer) and 10, 50 and 100 mg/kg (breast cancer)
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Administration:Intraperitoneal injection (i.p.), once daily for 5 days
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Result:Significantly slowed down the growth rate of the tumor.
Induced cell apoptosis in cancer cells removed from animals.
Chemical Information
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CAS. Nr. 84518-80-9
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Molecular Weight 521.60
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Formel C26H39N3O8
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SMILES
O=C(N1CCN(CC2=C(C(OC)=C(OC)C=C2)OC)CC1)[C@H](CC(C)C)NC([C@H]3[C@H](C(OCC)=O)O3)=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Toyo-oka T, et al. Reduction of experimentally produced acute myocardial infarction size by a new synthetic inhibitor, NCO-700, against calcium-activated neutral protease. Jpn Heart J. 1982 Sep;23(5):829-34. [Content Brief]
[2]. Eilon GF, et al. Tumor apoptosis induced by epoxide-containing piperazines, a new class of anti-cancer agents. Cancer Chemother Pharmacol. 2000;45(3):183-91. [Content Brief]
[3]. Sashida H, Abiko Y. Inhibition with NCO-700, a protease inhibitor, of degradation of cardiac myofibrillar proteins during ischemia in dogs. Biochem Pharmacol. 1985 Nov 1;34(21):3875-80. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
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