Physalin C
Physalin C is a natural product that can be found in physalis angulata. Physalin C shows cytotoxic activities against MCF-7 and HepG2 cells.
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- CAS. Nr.: 27503-33-9
- Formel: C28H30O9
- Molecular Weight:510.53
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Biologische Aktivität
Beschreibung
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HeLa | IC50 |
26.2 μM
Compound: PA-1
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Inhibition of TNFalpha-induced IkappaBalpha (unknown origin) phosphorylation expressed in human HeLa cells pretreated 30 mins before TNFalpha addition measured up to 120 mins by ELISA in presence of proteasome inhibitor MG-132
Inhibition of TNFalpha-induced IkappaBalpha (unknown origin) phosphorylation expressed in human HeLa cells pretreated 30 mins before TNFalpha addition measured up to 120 mins by ELISA in presence of proteasome inhibitor MG-132
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[PMID: 24900739] |
| HeLa | IC50 |
6.54 μM
Compound: PA-1
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Inhibition of TNFalpha-induced NF-kappaB activation (unknown origin) expressed in human HeLa cells pretreated 30 mins before TNFalpha addition after 7 hrs by luciferase reporter gene assay
Inhibition of TNFalpha-induced NF-kappaB activation (unknown origin) expressed in human HeLa cells pretreated 30 mins before TNFalpha addition after 7 hrs by luciferase reporter gene assay
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[PMID: 24900739] |
In Vitro
Physalin C (compound 6) (0-100 µM; 72 h) shows cytotoxic activities against MCF-7 and HepG2 cells with IC50s of 10.5, 24.2 µM, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MCF-7,HepG2 cells
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Concentration:0-100 µM
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Incubation Time:72 h
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Result:Showed cytotoxic activities with IC50s of 10.5, 24.2 µM for MCF-7,HepG2 cells, respectively.
Chemical Information
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CAS. Nr. 27503-33-9
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Molecular Weight 510.53
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Formel C28H30O9
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SMILES
C[C@@]12[C@]34[C@](C([C@](O3)([C@@]5([H])[C@]([C@@]6(C(CC=CC6=O)=CC5)C)([H])CC[C@@]4(C(O2)=O)O)O)=O)([H])[C@@]7(C[C@@]1([H])OC(C7=C)=O)C
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Structure Classification
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Initial Source
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Physalin C Related Classifications
HY-N8679 Related Classifications
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