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Art. -Nr.: HY-11039

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PU24FCl

PU24FCl is a specific inhibitor of Hsp90. PU24FCl exhibits wide-ranging anti-cancer activities. PU24FCl accumulates in tumors while being rapidly cleared from normal tissue.

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CAS. Nr.: 422508-46-1
Formel: C₂₀H₂₁ClFN₅O₃
Molecular Weight:433.86

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

PU24FCl Chemical Structure

CAS. Nr.: 422508-46-1

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Preis

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Menge

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

PU24FCl is a specific inhibitor of Hsp90. PU24FCl exhibits wide-ranging anti-cancer activities. PU24FCl accumulates in tumors while being rapidly cleared from normal tissue^[1].

IC₅₀ & Target

^[1]

HSP90

Alle HSP Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
HCT-116	GI₅₀	3.9 μM Compound: 8	Cellular activity against human colon tumor cell line, HCT116 Cellular activity against human colon tumor cell line, HCT116	[PMID: 14698151]
MCF7	IC₅₀	1.2 μM Compound: PUC24FCI	Antiproliferative activity against human MCF7 cells by MTS assay Antiproliferative activity against human MCF7 cells by MTS assay	[PMID: 17488003]
MCF7	IC₅₀	1.7 μM Compound: PUC24FCI	Inhibition of human recombinant HSP90 in MCF7 cells assessed as Her2 degradation Inhibition of human recombinant HSP90 in MCF7 cells assessed as Her2 degradation	[PMID: 17488003]
MCF7	IC₅₀	2.5 μM Compound: PUC24FCI	Binding affinity to human recombinant HSP90 in MCF7 cell lysates assessed as inhibition of biotinylated-geldanamycin binding Binding affinity to human recombinant HSP90 in MCF7 cell lysates assessed as inhibition of biotinylated-geldanamycin binding	[PMID: 17488003]
MCF7	IC₅₀	7 μM Compound: PUC24FCI	Selectivity for HSP90 in MCF7 cells over HSP90 in NDF cells Selectivity for HSP90 in MCF7 cells over HSP90 in NDF cells	[PMID: 17488003]
MDA-MB-468	EC₅₀	0.23 μM Compound: 4	Effective concentration against heat shock protein HSP90-alpha in MDA-MB-468 cells Effective concentration against heat shock protein HSP90-alpha in MDA-MB-468 cells	[PMID: 15828828]
SK-BR-3	IC₅₀	0.66 μM Compound: PU24FCl	Displacement of GM-cy3B from Hsp90 in human SKBR3 cells after 24 hrs by fluorescence polarization assay Displacement of GM-cy3B from Hsp90 in human SKBR3 cells after 24 hrs by fluorescence polarization assay	[PMID: 24548207]
SK-BR-3	IC₅₀	1.8 μM Compound: 4	Inhibitory concentration against SKBr3 cell line Inhibitory concentration against SKBr3 cell line	[PMID: 15828828]
SK-BR-3	IC₅₀	2 μM Compound: PU24FCl	Inhibition of Hsp70 in human SKBR3 cells assessed as HER2 protein degradation by Western blotting analysis Inhibition of Hsp70 in human SKBR3 cells assessed as HER2 protein degradation by Western blotting analysis	[PMID: 24548207]
SK-BR-3	IC₅₀	2.5 μM Compound: PU24FCl	Inhibition of Hsp70 in human SKBR3 cells assessed as RAF1 protein degradation by Western blotting analysis Inhibition of Hsp70 in human SKBR3 cells assessed as RAF1 protein degradation by Western blotting analysis	[PMID: 24548207]
SK-BR-3	IC₅₀	2.9 μM Compound: PU24FCl	Growth inhibition of human SKBR3 cells after 72 hrs by Alamar Blue assay Growth inhibition of human SKBR3 cells after 72 hrs by Alamar Blue assay	[PMID: 24548207]

Chemical Information

CAS. Nr. 422508-46-1
Molecular Weight 433.86
Formel C₂₀H₂₁ClFN₅O₃
SMILES

FC1=NC2=C(N=C(CC3=CC(OC)=C(C(OC)=C3Cl)OC)N2CCCC#C)C(N)=N1
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Vilenchik M, et, al. Targeting wide-range oncogenic transformation via PU24FCl, a specific inhibitor of tumor Hsp90. Chem Biol. 2004 Jun;11(6):787-97. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
Chemical Information
Reinheit & Dokumentation
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PU24FCl

Alle HSP Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Beschreibung

IC50 & Target

Cellular Effect

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

PU24FCl Related Classifications

HY-11039 Related Classifications

Bioz

Keywords

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