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Art. -Nr.: HY-B0279S1

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Ramipril-d₃

Name: Ramipril-d3
Brand: MedChemExpress
SKU: HY-B0279S1
Price: 770.00 USD
Availability: InStock
Rating: 5 (1 reviews)

(Synonyms: HOE-498-d₃)

Ramipril-d₃ (HOE-498-d₃) is the deuterated-labeled Ramipril (HY-B0279). Ramipril (HOE-498) is an orally active angiotensin-converting enzyme (ACE) inhibitor with blood-brain barrier permeability, and it is metabolized in vivo to the active metabolite Ramiprilat (HY-A0115). Ramipril has antioxidant, vasoprotective, and anti-atherosclerotic effects. Ramipril reduces the degradation of angiotensin II and bradykinin, downregulates TGF-beta/CTGF/fibronectin/α-SMA, and inhibits pancreatic/cardiac fibrosis. Ramipril improves glucose tolerance and insulin secretion, and reduces weight gain/appetite. Ramipril sensitizes mast cells, enhances FcεRI histamine release/degranulation, aggravates IgE allergic reactions, and downregulates the bradykinin receptor. Ramipril improves vascular endothelial relaxation function in spontaneously hypertensive rats. Ramipril alleviates Oxaliplatin (HY-17371)-induced acute hyperalgesia in mice. Ramipril can be used in research related to diseases such as type 2 diabetes, rheumatoid arthritis, allergy, and hypertension.

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CAS. Nr.: 2673269-81-1
Formel: C₂₃H₂₉D₃N₂O₅
Molecular Weight:419.53

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (291 KB)

Ramipril-d₃ Chemical Structure

CAS. Nr.: 2673269-81-1

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Anwendung
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

^[3]^[1]

Bradykinin B1 Receptor (B1R)

ACE

Alle Bradykinin Receptor Isoform-spezifische Produkte anzeigen :

Alle TGF-beta/Smad Isoform-spezifische Produkte anzeigen :

Smad1
Smad3

Anwendung

1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

Chemical Information

CAS. Nr. 2673269-81-1
Unlabeled CAS 87333-19-5
Molecular Weight 419.53
Formel C₂₃H₂₉D₃N₂O₅
SMILES

CCOC([C@H](CCC1=CC=CC=C1)N[C@@H](C([2H])([2H])[2H])C(N2[C@]3([H])[C@](CCC3)([H])C[C@H]2C(O)=O)=O)=O
Synonyms

HOE-498-d₃
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (291 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Ko SH, et al. Ramipril treatment suppresses islet fibrosis in Otsuka Long-Evans Tokushima fatty rats. Biochemical and biophysical research communications. 2004 Mar 26;316(1):114-22.

[2]. Shi Q, et al. Ramipril attenuates lipid peroxidation and cardiac fibrosis in an experimental model of rheumatoid arthritis. Arthritis research & therapy. 2012 Oct 18;14(5):R223.

[3]. Nassiri M, et al. Ramipril and metoprolol intake aggravate human and murine anaphylaxis: evidence for direct mast cell priming. The Journal of allergy and clinical immunology. 2015 Feb;135(2):491-9.

[4]. Hutri-Kähönen N, et al. Ramipril therapy improves arterial dilation in experimental hypertension. Cardiovascular research. 1997 Jan;33(1):188-95.

[5]. Bouchenaki H, et al. Ramipril Alleviates Oxaliplatin-Induced Acute Pain Syndrome in Mice. Frontiers in pharmacology. 2021;12:712442.

[6]. Jenrow KA, et al. Ramipril mitigates radiation-induced impairment of neurogenesis in the rat dentate gyrus. Radiat Oncol. 2010 Feb 1;5:6.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

MOQ

Minimum order quantity

100 mg

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Biologische Aktivität
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Chemical Information
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Ramipril-d₃

Alle Bradykinin Receptor Isoform-spezifische Produkte anzeigen

Alle TGF-beta/Smad Isoform-spezifische Produkte anzeigen