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Art. -Nr.: HY-184094

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Risimtinib

(Synonyms: Risimtinibum)

Risimtinib (Risimtinibum) is a FGFR1 inhibitor with an IC₅₀ of 2.1 nM. Risimtinib inhibits the proliferation of FGFR1-positive cancer cells. Risimtinib is used for the research of myeloid leukemia.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 2126751-11-7
Formel: C₃₀H₃₁N₅O₃
Molecular Weight:509.60

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Risimtinib Chemical Structure

CAS. Nr.: 2126751-11-7

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target^[1]

FGFR1

2.1 nM (IC₅₀)

In Vitro

Risimtinib (compound 19a) potently inhibits purified FGFR1 kinase activity with an IC₅₀ of 2.1 nM^[1].
Risimtinib inhibits the proliferation of FGFR1-translocated KG-1 leukemia cells with an IC₅₀ of 14.9 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 2126751-11-7
Molecular Weight 509.60
Formel C₃₀H₃₁N₅O₃
SMILES

CNC(C1=CC=CC2=C1C=CC(OC3=CC=NC(NC(C4=CC=C(N5C[C@H](N[C@H](C5)C)C)C=C4)=O)=C3)=C2)=O
Synonyms

Risimtinibum
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Wei M, et al. Design, synthesis and biological evaluation of a series of novel 2-benzamide-4-(6-oxy-N-methyl-1-naphthamide)-pyridine derivatives as potent fibroblast growth factor receptor (FGFR) inhibitors. European journal of medicinal chemistry. 2018 Jun 25;154:9-28. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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