country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Art. -Nr.: HY-123958

Copy Link Print Information

SB772077B

SB772077B is a ROCK inhibitor. SB772077B has an anti-inflammatory activity and enhances aqueous outflow facility (OF) by inactivating RhoA/ROCK signal pathway. SB772077B significantly reduces the mRNA level of β-catenin and protein level of fibrotic markers, such as vinculin, fibronectin, collagen 1 A and vimentin. SB772077B also has vasodialatory activity and decreases pulmonary and systemic blood pressure. SB772077B can be used for glaucoma research and pulmonary hypertensive disorder research.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 785774-34-7

Formel: C₁₅H₁₈N₈O₂

Molecular Weight:342.36

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

SB772077B Chemical Structure

CAS. Nr.: 785774-34-7

Fast delivery

Free and easy returns

Größe

Preis

Verfügbarkeit

Menge

MOQ

Minimum order quantity

Sample (0.1mg)

In-stock

(In Japan)

Apply Now

Angebot einholen Ask For Quote & Lead Time Consult sales personnel for more information Check price and availability Angebot einholen Ask For Quote & Lead Time Consult sales personnel for more information Check price and availability

Massenanfrage

Other size

Angebot einholen

Get it by August 31for select sizes. Order within 11 hrs 49 mins.

This product is a controlled substance, please contact local distributor for purchase. This product is a controlled substance and not for sale in your territory.

Amount: USD 0.00

Please select quantity

or

or

* Bitte wählen Sie Menge, bevor Sie Artikel hinzufügen.

To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

This product is not for sale in your territory.

Data Download

Data Sheet (270 KB)

Handling Instructions (2659 KB)

Other Forms of SB772077B:

SB-772077B dihydrochloride
Auf Lager

To place orders, for customer services and technical support, please contact:

609-228-6898

[email protected] [email protected]

Finden Sie Ihren Händler vor Ort Your local distributor: Hycultec GmbHHycultec

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Help & FAQs

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Alle ROCK Isoform-spezifische Produkte anzeigen
More

ROCK

ROCK1

ROCK2

Biologische Aktivität

Beschreibung

IC₅₀ & Target

Cellular Effect

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

Classifications

Bioz

Biologische Aktivität

Beschreibung

SB772077B is a ROCK inhibitor. SB772077B has an anti-inflammatory activity and enhances aqueous outflow facility (OF) by inactivating RhoA/ROCK signal pathway. SB772077B significantly reduces the mRNA level of β-catenin and protein level of fibrotic markers, such as vinculin, fibronectin, collagen 1 A and vimentin. SB772077B also has vasodialatory activity and decreases pulmonary and systemic blood pressure. SB772077B can be used for glaucoma research and pulmonary hypertensive disorder research^[1]^[2].

IC₅₀ & Target^[1]

Collagen I

Alle ROCK Isoform-spezifische Produkte anzeigen :

ROCK

ROCK1

ROCK2

Cellular Effect

Cell Line

Type Value Description References

Sf9 IC₅₀
5.6 nM
Compound: SB-7720770-B

Inhibition of human recombinant N-terminal his-tagged ROCK1 (3-543) expressed in baculovirus infected Sf9 cells using Biotin-Ahx-AKRRLSSLRA-CONH2 substrate and [gamma-33P]ATP after 90 mins by scintillation proximity assay

Inhibition of human recombinant N-terminal his-tagged ROCK1 (3-543) expressed in baculovirus infected Sf9 cells using Biotin-Ahx-AKRRLSSLRA-CONH2 substrate and [gamma-33P]ATP after 90 mins by scintillation proximity assay
[PMID: 17018693]

Sf9 IC₅₀
5.6 nM
Compound: SB-772077-B

Inhibition of N-terminal His-tagged human ROCK1 (3 to 543 residues) expressed in baculovirus infected Sf9 cells using biotin-Ahx-AKRRRLSSLRA-CONH2 as substrate incubated for 90 mins in presence of [gamma33P]ATP by scintillation counting method

Inhibition of N-terminal His-tagged human ROCK1 (3 to 543 residues) expressed in baculovirus infected Sf9 cells using biotin-Ahx-AKRRRLSSLRA-CONH2 as substrate incubated for 90 mins in presence of [gamma33P]ATP by scintillation counting method
[PMID: 31330446]

Chemical Information

CAS. Nr. 785774-34-7

Molecular Weight 342.36

Formel C₁₅H₁₈N₈O₂

SMILES

NC1=NON=C1C(N2CC)=NC3=C2C(C(N4C[C@@H](N)CC4)=O)=CN=C3

Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)

COA (2659 KB)

Elemental Analysis Report (2659 KB)

HNMR (2659 KB)

CNMR (2659 KB)

RP-HPLC (2659 KB)

NP-HPLC (2659 KB)

MS (2659 KB)

LCMS (2659 KB)

IR (2659 KB)

GC (2659 KB)

OR (2659 KB)

SDS-PAGE (2659 KB)

SEC-HPLC (2659 KB)

Other Report (2659 KB)

Handling Instructions (2659 KB)

Verweise

[1]. Ashwinbalaji S, et al. SB772077B, A New Rho Kinase Inhibitor Enhances Aqueous Humour Outflow Facility in Human Eyes. Sci Rep. 2018 Oct 19;8(1):15472. [Content Brief]

[2]. Dhaliwal J S, et al. Analysis of pulmonary vasodilator responses to SB-772077-B [4-(7-((3-amino-1-pyrrolidinyl) carbonyl)-1-ethyl-1H-imidazo (4, 5-c) pyridin-2-yl)-1, 2, 5-oxadiazol-3-amine], a novel aminofurazan-based Rho kinase inhibitor[J]. The Journal of pharmacology and experimental therapeutics, 2009, 330(1): 334-341.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

=
Konzentration Konzentration

×
Volumen Volumen

×
Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

×

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

=

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

×

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

SB772077B Related Classifications

HY-123958 Related Classifications

Cell Cycle/DNA Damage TGF-beta/Smad Stem Cell/Wnt Cytoskeleton

ROCK β-catenin Collagen

Disease Areas

Neurological, Eye or Ear Disease Blood or Cardio-cerebrovascular Disease Inflammation or Immune System Disease

Visual System Disease Cardiovascular Disease

Glaucoma Hypertension

Neurological Disease Inflammation/Immunology Cardiovascular Disease

Powered by Bioz See more details on Bioz

Keywords

SB772077B
785774-34-7
ROCK
β-catenin
Collagen
HTM cells
aqueous outflow facility
RhoA/ROCK
anti-inflammatory
vasodialatory
glaucoma
pulmonary hypertensive disorder
Inhibitor
inhibitor
inhibit

Your Recently Viewed Products

SB772077B

100 mg Angebot einholen

Subscribe to the

MedChemExpress

Newsletter

Subscribe

Cell Line	Type	Value	Description	References
Sf9	IC₅₀	5.6 nM Compound: SB-7720770-B	Inhibition of human recombinant N-terminal his-tagged ROCK1 (3-543) expressed in baculovirus infected Sf9 cells using Biotin-Ahx-AKRRLSSLRA-CONH2 substrate and [gamma-33P]ATP after 90 mins by scintillation proximity assay Inhibition of human recombinant N-terminal his-tagged ROCK1 (3-543) expressed in baculovirus infected Sf9 cells using Biotin-Ahx-AKRRLSSLRA-CONH2 substrate and [gamma-33P]ATP after 90 mins by scintillation proximity assay	[PMID: 17018693]
Sf9	IC₅₀	5.6 nM Compound: SB-772077-B	Inhibition of N-terminal His-tagged human ROCK1 (3 to 543 residues) expressed in baculovirus infected Sf9 cells using biotin-Ahx-AKRRRLSSLRA-CONH2 as substrate incubated for 90 mins in presence of [gamma33P]ATP by scintillation counting method Inhibition of N-terminal His-tagged human ROCK1 (3 to 543 residues) expressed in baculovirus infected Sf9 cells using biotin-Ahx-AKRRRLSSLRA-CONH2 as substrate incubated for 90 mins in presence of [gamma33P]ATP by scintillation counting method	[PMID: 31330446]

100 mg

Angebot einholen Auf Lager

Please select quantity

Amount: USD 0.00

Biologische Aktivität

Beschreibung

IC₅₀ & Target

Chemical Information

Reinheit & Dokumentation

Verweise

Sign in to MedChemExpress Einloggen

Registrieren

Sign in to MedChemExpress

Keep me logged in. Passwort vergessen

Neuen Account Registrieren

At least 6 characters

Personalize your experience, you are currently not signed in. For a better experience, please create an online profile, you can:

Obtain points redemption prizes

Check out faster

Add multiple shipping locations

View orders

Assay Types

1/16

Online-Anfrage

Your information is safe with us. *Required Fields.

Produktname *
Field is required.

Requested Quantity *
Field is required.

Name des Bewerbers *
Field is required.

Salutation *
Field is required.

Email *
Field is required.

Please enter a valid Email Address.

Telefonnummer *
Field is required.

Department

Name der Organisation *
Field is required.

Stadt

Bundesland Bundesland *
Field is required.

Land oder Region *
Field is required.

Container *
Field is required.

MCE Japan Authorized Agent:

ナミキ商事株式会社コスモ・バイオ株式会社重松貿易株式会社

Bemerkungen

Request for Report

Please fill out this form to request the report. We will send it to your Email address shortly.
Your information is safe with us. *Required Fields.

Produktname *
Field is required.

Lot # *
Field is required.

Name des Bewerbers *
Field is required.

Email *
Field is required.

Please enter a valid Email Address.

Telefonnummer
Field is required.

Department *
Field is required.

Name der Organisation *
Field is required.

Land oder Region *
Field is required.

Bemerkungen

Massenanfrage Request for Report Online-Anfrage Kundenbewertung Request for Recombinant Proteins Catalog

We have received your request and will respond to you as soon as possible. Congratulations! Uh-oh!

We have received your inquiry regarding and will respond to you as soon as possible. We have received your request and will respond to you as soon as possible. Thank You for Your Feedback! This product is a controlled substance and not for sale in your territory. It appears that we were unable to send an email to . Please verify your email address and try again!

Inquiry Information

Produktname:

Art. -Nr.:

Menge:

MCE Japan Authorized Agent:

Inquiry Information

Produktname:

CAS. Nr.:

Species:

Reinheit:

Menge:

Licensing Opportunities

Your information is safe with us. *Required Fields.

Name des Bewerbers *
Field is required.

Salutation *
Field is required.

Role/Position *
Field is required.

Name der Organisation *
Field is required.

Land oder Region *
Field is required.

Bundesland Bundesland *
Field is required.

Email *
Field is required.

Please enter a valid Email Address.

Telefonnummer *
Field is required.

Produktname
Field is required.

CAS. Nr.
Field is required.

Bemerkungen

MedChemExpress

MedChemExpress

Contact Us

About Us

Headquarters

Distributors

Statement on False Report

Careers

Kunden Service

Kunden Service

Technical Support

Dienstleistungen

Ordering Information

Easy Return

Versandkosten & Richtlinien

Terms & Conditions

Intellectual Property Promise

Ressourcen

Ressourcen

Richtlinien für Kostenlose Proben

Scientific Reviews

Topics

Product Guides

Blogs

Protocols

Brochures

Promotions

Events and Webinars

Genes

Biomedical Dictionary

Subscribe to our E-newsletter

Sorry, but the email address you supplied was invalid.

Thanks, your subscription has been confirmed. You will hear from us soon.

Submission failed, please try again later.

Produkte sind chemische Reagenzien, die nur für Forschungszwecke bestimmt sind und nicht für den menschlichen Gebrauch. Wir verkaufen nicht an Patienten.

Copyright © 2013-2026 MedChemExpress. All Rights Reserved.

Site Map | Privacy and Cookie Policy

Online Service Online Customer Service

Contact Us

Happy to help!

MedChemExpress

Tel: 609-228-6898

E-mail: [email protected]

Technical Support: [email protected]

MedChemExpress

We use cookies

MedChemExpress values your privacy and your trust is important to us. We use cookies to enhance your website experience. Some cookies are necessary to run the website. Privacy and Cookie Policy