SR8185
SR8185 is a potent and selective TBK1/IKKi dual inhibitor with IC50s of 3 nM and < 10 nM against IKKi and TBK1, respectively. SR8185 exhibits potent and broad spectrum antiproliferative effects on human cancer cells. SR8185 can be used for cancer research.
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- CAS. Nr.: 1356225-62-1
- Formel: C26H27N7O
- Molecular Weight:453.54
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
- Protokoll
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
Beschreibung
IC50 & Target
[1]|
IKKi 3 nM (IC50) |
TBK1 <10 nM (IC50) |
In Vitro
SR8185 (72 h) exhibits potent and broad spectrum antiproliferative activity against a panel of human cancer cells, with IC50s of 1.901 (SCC-9), 0.651 (SCC-15), 1.641 (SCC-25), 0.611 (PC3), 0.532 (DU145),0.550 (LNCaP), 0.463 (Myc-CaP), 0.541 (MCF-7), 1.772 (MDA-MB-231), and 0.613 µM (T-47D), respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS. Nr. 1356225-62-1
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Molecular Weight 453.54
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Formel C26H27N7O
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SMILES
O=C(N1CCCC1)NC2=CC=CC(NC3=NC=CC(C4=CC=C(N5CCCC5)C(C#N)=C4)=N3)=C2
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Protokoll
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Cell Viability Determination by MTT Colorimetric Assay
The following protocol uses the MTT colorimetric assay as a classic literature-established method for assessing cell viability/metabolic activity in cultured mammalian cells. MTT[3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] is reduced by metabolically active cells to a colored formazan product; the amount of formazan is quantified spectrophotometrically and provides an indirect measure of metabolically active viable cells. Importantly, MTT reduction reflects cellular oxidoreductase/metabolic activity rather than an absolute direct count of living cells, so changes in cellular metabolism can alter the signal independently of cell number.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
SR8185 Related Classifications
HY-148483 Related Classifications
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