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Art. -Nr.: HY-187308

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STK189682

STK189682 is an ATPase inhibitor targeting MDA5, LGP2 and DDX1, with IC₅₀ values of 7 μM, 7 μM and 5 μM, respectively. STK189682 binds to the MDA5-ATP complex in an ATP-noncompetitive manner and does not compete with RNA.

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CAS. Nr.: 765922-18-7
Formel: C₂₁H₁₆N₄O₄S₂
Molecular Weight:452.51

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

STK189682 Chemical Structure

CAS. Nr.: 765922-18-7

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Beschreibung

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In Vitro

STK189682 potently inhibits the ATPase activities of recombinant MDA5 (IC₅₀ = 7 μM), LGP2 (IC₅₀ = 7 μM) and DDX1 (IC₅₀ = 5 μM)^[1].
STK189682 is an ATP-uncompetitive inhibitor of recombinant MDA5, which is evidenced by the observation that its IC₅₀ value decreases as ATP concentration increases^[1].
STK189682 does not compete with RNA for binding to recombinant MDA5, as the IC₅₀ value remains unchanged with increasing RNA concentrations^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 765922-18-7
Molecular Weight 452.51
Formel C₂₁H₁₆N₄O₄S₂
SMILES

O=C(C1=CC=C(NC2=NC(C3=C(C)N=C(NC(C4=CC=CC=C4)=O)S3)=CS2)C=C1O)O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Wang X, et al. Identification and optimization of first-in-class RNA helicase inhibitors of DDX1, LGP2, and MDA5. European journal of medicinal chemistry. 2026 May 05;309:118724. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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STK189682

Alle DNA/RNA Synthesis Isoform-spezifische Produkte anzeigen

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STK189682 Related Classifications

HY-187308 Related Classifications