STM3006
Based on 2 publication(s) in Google Scholar
STM3006 is a highly potent, selective, and orally active inhibitor of METTL3 (IC50: 5 nM). STM3006 can reduce the m6A level, promote the formation of dsRNA, trigger a cell-intrinsic interferon response, and enhance the killing effect of T cells on tumors. STM3006 has anti-tumor activity, and its combination with anti-PD-1 immunotherapy yields better results.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 99.79%
- CAS. Nr.: 2499664-52-5
- Formel: C25H27BrN8
- Molecular Weight:519.44
-
Speicherung:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biologische Aktivität
-
Chemical Information
-
Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
-
Help & FAQs
Publications Citing Use of MedChemExpress (MCE) STM3006
More
Biologische Aktivität
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| Caov-3 cell line | IC50 |
182 nM
Compound: 6e
|
Antiproliferative activity against human Caov-3 cell line assessed as inhibition of cell proliferation and measured after 7 days by CellTiter-Glo assay
Antiproliferative activity against human Caov-3 cell line assessed as inhibition of cell proliferation and measured after 7 days by CellTiter-Glo assay
|
[PMID: 36692498] |
| Huh-7 | GI50 |
0.18 μM
Compound: 9; STM3006
|
Growth inhibition of human Huh-7 cells
Growth inhibition of human Huh-7 cells
|
[PMID: 38805939] |
| MOLM-13 | IC50 |
338 μM
Compound: 6e
|
Antiproliferative activity against human MOLM-13 cells assessed as inhibition of cell proliferation and measured after 7 days by CellTiter-Glo assay
Antiproliferative activity against human MOLM-13 cells assessed as inhibition of cell proliferation and measured after 7 days by CellTiter-Glo assay
|
[PMID: 36692498] |
STM3006 (0.1-0.5 μM; 30 h) can promote interferon activation and the expression of related genes in CaOV3[1].
STM3006 (0.3-3 μM; 48 h) enhances the killing effect of T cells on tumor cells in the co-culture experiment of mouse B16-ovalbumin tumor cells and OT-I T cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:CaOV3 cells
-
Concentration:0.1 and 0.5 μmol/L
-
Incubation Time:30 h
-
Result:Enhanced the expression levels of MDA-5, IFIT1, OAS2, and ISG15.
Chemical Information
-
CAS. Nr. 2499664-52-5
-
Appearance Solid
-
Molecular Weight 519.44
-
Formel C25H27BrN8
-
Color Light yellow to brown
-
SMILES
BrC1=CC(C2=CN(CC3=CN4C=C(CN5CCC(C)(CC5)C)C=CC4=N3)N=N2)=C6C=NNC6=C1
-
Versand
Room temperature in continental US; may vary elsewhere.
-
Speicherung
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (2)
-
Journal Impact Factor
-
Most Recent
-
bioRxiv
2026 Mar 18:2026.03.18.712554. PMID: 41890003 -
Lösungsmittel & Löslichkeit
DMSO : ≥ 100 mg/mL (192.52 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
-
Data Sheet (274 KB)
-
SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
-
Handling Instructions (2659 KB)
Verweise
[1]. Andrew A Guirguis, et al. Inhibition of METTL3 Results in a Cell-Intrinsic Interferon Response That Enhances Antitumor Immunity.Cancer Discov. 2023 Oct 5;13(10):2228-2247. [Content Brief]
[2]. Brichkina A, et al. Methyltransferase-like 3 (METTL3) inhibition potentiates anti-tumor immunity: a novel strategy for improving anti-PD1 therapy. Signal Transduct Target Ther. 2023 Dec 11;8(1):448. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.9252 mL | 9.6258 mL | 19.2515 mL | 48.1288 mL |
| 5 mM | 0.3850 mL | 1.9252 mL | 3.8503 mL | 9.6258 mL | |
| 10 mM | 0.1925 mL | 0.9626 mL | 1.9252 mL | 4.8129 mL | |
| 15 mM | 0.1283 mL | 0.6417 mL | 1.2834 mL | 3.2086 mL | |
| 20 mM | 0.0963 mL | 0.4813 mL | 0.9626 mL | 2.4064 mL | |
| 25 mM | 0.0770 mL | 0.3850 mL | 0.7701 mL | 1.9252 mL | |
| 30 mM | 0.0642 mL | 0.3209 mL | 0.6417 mL | 1.6043 mL | |
| 40 mM | 0.0481 mL | 0.2406 mL | 0.4813 mL | 1.2032 mL | |
| 50 mM | 0.0385 mL | 0.1925 mL | 0.3850 mL | 0.9626 mL | |
| 60 mM | 0.0321 mL | 0.1604 mL | 0.3209 mL | 0.8021 mL | |
| 80 mM | 0.0241 mL | 0.1203 mL | 0.2406 mL | 0.6016 mL | |
| 100 mM | 0.0193 mL | 0.0963 mL | 0.1925 mL | 0.4813 mL |
STM3006 Related Classifications
HY-156773 Related Classifications
Powered by Bioz