UM-259
UM-259 is a STING inhibitor, with an EC50 of 1.50 μM in THP1-Dual cells expressing wild-type STING. UM-259 blocks STING oligomerization and inhibits diABZI-induced phosphorylation of TBK1 and IRF3, thereby suppressing the transcription of IFNβ and IL6 and reducing IFNβ secretion. UM-259 can be used for the study of STING-dependent inflammatory and neurological diseases.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Formel: C27H21F2N7O5
- Molecular Weight:561.50
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
UM-259 (0.2-5 μM, pretreated for 1 h) exerts potent inhibitory activity on diABZI-induced IFNβ and IL6 gene transcription in iBMDMs[1].
UM-259 (2.5 μM, pretreated for 1 h) displays potent activity in blocking STING-dependent IFNβ secretion in primary human CD14+ monocytes[1].
UM-259 (5 μM, pretreated for 1 h) shows potent inhibitory activity on diABZI-induced phosphorylation of TBK1 and IRF3and exhibits potent activity in inhibiting STING oligomerization in WT BMDMs, effectively blocking STING downstream signal transduction[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:WT BMDMs
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Concentration:5 μM
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Incubation Time:Pretreated for 1 h
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Result:Showed potent inhibitory activity on diABZI-induced phosphorylation of TBK1 and IRF3.
Exhibited potent activity in inhibiting STING oligomerization in WT BMDMs.
Chemical Information
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Molecular Weight 561.50
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Formel C27H21F2N7O5
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SMILES
O=C(C1=NOC(C2=CC=C(F)C=C2F)=C1)NC3(C4=NC5=CC=CC=C5N4)CCN(C(C6=CC=C([N+]([O-])=O)O6)=N)CC3
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
UM-259 Related Classifications
HY-178049 Related Classifications
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