NADPH tetracyclohexanamine
Based on 18 publication(s) in Google Scholar
NADPH tetracyclohexanamine functions as an important cofactor in a variety of metabolic and biosynthetic pathways. NADPH tetracyclohexanamine is an endogenous inhibitor of ferroptosis. NADPH tetracyclohexanamine plays a vital role in the biosynthesis of agents, chiral alcohols, fatty acids and biopolymers, while also being required for lipid biosynthesis, biomass formation, and cell replication.
For research use only. We do not sell to patients.
- Purity: 98.07%
- CAS No.: 100929-71-3
- Formula: C45H82N11O17P3
- Molecular Weight:1142.12
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) NADPH tetracyclohexanamine
More- Adv Sci (Weinh). 2025 Sep 15:e07283. [Abstract]
- Sci Adv. 2025 Dec 19;11(51):eady2104. [Abstract]
- Cell Rep Phys Sci. 2025 Mar 19.
- J Med Chem. 2025 Dec 25;68(24):26383-26404. [Abstract]
- J Agric Food Chem. 2024 Sep 11;72(36):20064-20076. [Abstract]
- Chem Biol Interact. 2022 Dec 1:368:110222. [Abstract]
- Mol Ther Oncol. 2024 Sep 17;32(4):200878. [Abstract]
- Drug Des Devel Ther. 2020 Nov 30;14:5259-5273. [Abstract]
- Mol Plant Pathol. 2025 Dec;26(12):e70196. [Abstract]
- J Mol Struct. 2026 Mar 10.
- Eur J Pharm Sci. 2021 Sep 1:164:105889. [Abstract]
- iScience. 2024 Aug 30;27(9):110834. [Abstract]
- Microbiol Spectr. 2023 Sep 21;11(5):e0267123. [Abstract]
- Xenobiotica. 2022 Feb;52(2):165-176. [Abstract]
- Res Sq. 2026 Jan 12.
- Chemrxiv. 2025 Aug 28.
- JID Innov. 2023 Nov 28;4(2):100251. [Abstract]
- Research Square Preprint. 2023 Jul 31.
Customer Validation & Images
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Cell Imaging/Staining
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WB
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Cell Imaging/Staining
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Bio/Physico-chemical Assay
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Cell Proliferation/Viability Assay
All Endogenous Metabolite Isoforms
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Biological Activity
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Human Endogenous Metabolite |
The regeneration rate of NADPH tetracyclohexanamine is often the rate-limiting step for the over-production of desired chemicals, while maintaining robust cellular growth[2].
NADPH tetracyclohexanamine homeostasis is regulated by varied signaling pathways and several metabolic enzymes that undergo adaptive alteration in cancer cells. The metabolic reprogramming of NADPH tetracyclohexanamine renders cancer cells both highly dependent on this metabolic network for antioxidant capacity and more susceptible to oxidative stress[3].
NADPH tetracyclohexanamine is an essential intracellular reductant needed to eliminate lipid hydroperoxides. Indeed, NADPH tetracyclohexanamine levels are a biomarker of ferroptosis sensitivity across many cancer cell lines[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 100929-71-3
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Appearance Solid
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Molecular Weight 1142.12
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Formula C45H82N11O17P3
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Color White to light yellow
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SMILES
O[C@H]1[C@@H](O)[C@H](N2C=C(C(N)=O)CC=C2)O[C@@H]1COP(O)(OP(OC[C@@H]3[C@@H](O)[C@@H](OP(O)(O)=O)[C@H](N(C4=NC=N5)C=NC4=C5N)O3)(O)=O)=O.NC6CCCCC6.NC7CCCCC7.NC8CCCCC8.NC9CCCCC9
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (18)
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Journal Impact Factor
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Most Recent
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Adv Sci (Weinh)
Redox Cascade in Chicken Skeletal Muscle: SELENOT Suppression in Selenium Deficiency Triggers Disulfidptosis via mtROS-NADPH Dysregulation. [Abstract]2025 Sep 15:e07283. PMID: 40953299
NADPH tetracyclohexanamine purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Sep 15:e07283. [Abstract]
A normal cellular state was recovered by adding TEMPO or NADPH (1mM, 24h), or SLC7A11 knockdown.
NADPH tetracyclohexanamine purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Sep 15:e07283. [Abstract]
Western Blot analysis of RAC/WAVE pathway-related indicators in vitro skeletal muscle cells. Muscle cells treated with different condition NADPH(1mM, 24h).
NADPH tetracyclohexanamine purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Sep 15:e07283. [Abstract]
mtROS fluorescence staining of skeletal muscle cells in vitro. Muscle cells treated with different condition NADPH(1mM, 24h).
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Sci Adv
Direct recruitment of TONSOKU by the N-terminal tails of histone variants H2A.X and H2A.W coordinates DNA repair. [Abstract]2025 Dec 19;11(51):eady2104. PMID: 41406205 -
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J Med Chem
Discovery of Novel Bifunctional Agents as Potent TRK Inhibitors and Degraders against xDFG Mutation Resistance. [Abstract]2025 Dec 25;68(24):26383-26404. PMID: 41345987 -
J Agric Food Chem
2024 Sep 11;72(36):20064-20076. PMID: 39196852 -
Chem Biol Interact
Discovery and characterization of the flavonoids in Cortex Mori Radicis as naturally occurring inhibitors against intestinal nitroreductases. [Abstract]2022 Dec 1:368:110222. PMID: 36244406 -
Mol Ther Oncol
AVL-armed oncolytic vaccinia virus promotes viral replication and boosts antitumor immunity via increasing ROS levels in pancreatic cancer. [Abstract]2024 Sep 17;32(4):200878. PMID: 39431173
NADPH tetracyclohexanamine purchased from MedChemExpress. Usage Cited in: Mol Ther Oncol. 2024 Sep 17;32(4):200878. [Abstract]
Apoptosis proportion of oncoVV-AVL-treated AsPC-1(Up) and PANC-1 (Down) cells treated with NADPH (300 μM) or NADH. Data are presented as the mean ± SD (n=3).
NADPH tetracyclohexanamine purchased from MedChemExpress. Usage Cited in: Mol Ther Oncol. 2024 Sep 17;32(4):200878. [Abstract]
Western blotting detection of the expressions of caspase-3 and caspase-9 in oncoVV or oncoVV-AVL-treated AsPC-1(Up) and PANC-1 (Down) cells treated with NADPH (300 μM).
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Drug Des Devel Ther
Characterization of Stable and Reactive Metabolites of the Anticancer Drug, Ensartinib, in Human Liver Microsomes Using LC-MS/MS: An in silico and Practical Bioactivation Approach. [Abstract]2020 Nov 30;14:5259-5273. PMID: 33299299 -
Mol Plant Pathol
Negative Immune Regulator CAD7 Functions as a Small-Molecule Aldehyde Reductase and Increases Histamine Accumulation in Arabidopsis. [Abstract]2025 Dec;26(12):e70196. PMID: 41456913
NADPH tetracyclohexanamine purchased from MedChemExpress. Usage Cited in: Mol Plant Pathol. 2025 Dec;26(12):e70196. [Abstract]
Enzymatic activities of AtCAD7, AtCAD5, EcYahK, and EcYjgB toward (Z)‐3‐hexenal, acrolein, isovaleraldehyde, salicylaldehyde, and p‐coumaryl aldehyde. No Substrate was negative control. Assays were conducted under standardised conditions (30°C, pH 6.5, 100 μM substrate, 200 μM NADPH).
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Eur J Pharm Sci
Atypical kinetics of cytochrome P450 2J2: Epoxidation of arachidonic acid and reversible inhibition by xenobiotic inhibitors. [Abstract]2021 Sep 1:164:105889. PMID: 34044117 -
iScience
2024 Aug 30;27(9):110834. PMID: 39310768 -
Microbiol Spectr
Potential quorum-sensing inhibitor of Hafnia alvei H4-theaflavin-3,3´-digallate analyzed by virtual screening and molecular simulation. [Abstract]2023 Sep 21;11(5):e0267123. PMID: 37732782 -
Xenobiotica
Metabolites identification and species comparison of Oroxylin A, an anti-cancer flavonoid, in vitro and in vivo by HPLC-Q-TOF-MS/MS. [Abstract]2022 Feb;52(2):165-176. PMID: 35345974 -
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JID Innov
ATI-1777, a Topical Jak1/3 Inhibitor, May Benefit Atopic Dermatitis without Systemic Drug Exposure: Results from Preclinical Development and Phase 2a Randomized Control Study ATI-1777-AD-201. [Abstract]2023 Nov 28;4(2):100251. PMID: 38299059 -
Solvent & Solubility
H2O : ≥ 100 mg/mL (87.56 mM)
DMSO : ≥ 84 mg/mL (73.55 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (251 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / H2O | 1 mM | 0.8756 mL | 4.3778 mL | 8.7556 mL | 21.8891 mL |
| 5 mM | 0.1751 mL | 0.8756 mL | 1.7511 mL | 4.3778 mL | |
| 10 mM | 0.0876 mL | 0.4378 mL | 0.8756 mL | 2.1889 mL | |
| 15 mM | 0.0584 mL | 0.2919 mL | 0.5837 mL | 1.4593 mL | |
| 20 mM | 0.0438 mL | 0.2189 mL | 0.4378 mL | 1.0945 mL | |
| 25 mM | 0.0350 mL | 0.1751 mL | 0.3502 mL | 0.8756 mL | |
| 30 mM | 0.0292 mL | 0.1459 mL | 0.2919 mL | 0.7296 mL | |
| 40 mM | 0.0219 mL | 0.1094 mL | 0.2189 mL | 0.5472 mL | |
| 50 mM | 0.0175 mL | 0.0876 mL | 0.1751 mL | 0.4378 mL | |
| 60 mM | 0.0146 mL | 0.0730 mL | 0.1459 mL | 0.3648 mL | |
| H2O | 80 mM | 0.0109 mL | 0.0547 mL | 0.1094 mL | 0.2736 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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