A11
Based on 1 Customer Validation
A11 (ANXA1-derived 11 amino acid-long peptide) is a ANXA1-EphA2 interaction-blocking peptide. A11 reduces ANXA1 bound to EphA2 and increases Cbl (the E3 ubiquitin ligase of EphA2) bound to EphA2. A11 inhibits the proliferation, migration and invasion of nasopharyngeal carcinoma cells. A11 inhibits angiogenesis. A11 can be used in studies related to nasopharyngeal carcinoma.
For research use only. We do not sell to patients.
- Purity: 98.49%
- CAS No.: 2412926-30-6
- Formula: C117H204N46O32
- Molecular Weight:2767.16
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Storage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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AnxA1 |
A11 (2.5-10 μM; 24 h) blocks the binding of ANXA1 to EphA2, enhances the binding of Cbl to EphA2, reduces the protein level of EphA2 in human nasopharyngeal carcinoma 5-8F and HK1 cells in a dose-dependent manner, and promotes the ubiquitination and endocytosis of EphA2, with the strongest effect observed after 24 h of incubation at the treatment concentration of 10 μM[1].
A11 (10 μM; 10 days) significantly inhibits the proliferation and anchorage-independent growth of human nasopharyngeal carcinoma 5-8F and HK1 cells[1].
A11 (10 μM; 24-48 h) significantly inhibits the migration and invasion of human nasopharyngeal carcinoma 5-8F and HK1 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:human NPC 5-8F and HK1 cells
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Concentration:10 μM
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Incubation Time:refreshed every 24 h for 10 days
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Result:Reduced EdU-positive 5-8F cells from ~34% to ~14% and EdU-positive HK1 cells from ~26% to ~12%.
Reduced colony formation in 5-8F cells from ~350 colonies to ~100 colonies and in HK1 cells from ~300 colonies to ~50 colonies.
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Cell Line:human NPC 5-8F and HK1 cells
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Concentration:10 μM
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Incubation Time:24 and 48 h
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Result:Significantly inhibited the invasion.
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Cell Line:human NPC 5-8F and HK1 cells
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Concentration:10 μM
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Incubation Time:24 and 48 h
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Result:Significantly inhibited the migration.
Chemical Information
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CAS No. 2412926-30-6
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Appearance Solid
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Molecular Weight 2767.16
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Formula C117H204N46O32
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Color White to off-white
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Synonyms
ANXA1-derived 11 amino acid-long peptide
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Sequence
Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Glu-Tyr-Val-Gln-Thr-Val-Lys-Ser-Ser-Lys-Gly
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Sequence Shortening
YGRKKRRQRRREYVQTVKSSKG
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 33.33 mg/mL (12.04 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 22.2 mg/mL (8.02 mM; Need ultrasonic and warming)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (279 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 0.3614 mL | 1.8069 mL | 3.6138 mL | 9.0345 mL |
| 5 mM | 0.0723 mL | 0.3614 mL | 0.7228 mL | 1.8069 mL | |
| DMSO | 10 mM | 0.0361 mL | 0.1807 mL | 0.3614 mL | 0.9035 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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