MPX-004
Based on 1 Customer Validation
MPX-004 is a potent GluN2A antagonist. MPX-004 inhibits GluN2A-containing NMDA receptors expressed in HEK cells with an IC50 of 79 nM. MPX-004 has no inhibitory effect on GluN2B or GluN2D receptor-mediated responses. MPX-004 has the potential for neuropsychiatric and developmental disorders research.
For research use only. We do not sell to patients.
- Purity : 99.58%
- CAS No.: 1688684-07-2
- Formula: C17H15ClFN5O3S2
- Molecular Weight:455.91
-
Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Protocols
- Purity & Documentation
- References
-
Help & FAQs
All iGluR Isoforms
More
Biological Activity
Description
IC50 & Target
[1]|
5-HT1B Receptor |
NMDA Receptor |
In Vitro
MPX-004 inhibits NMDA receptor-mediated currents in Xenopus oocytes expressing human GluN1 + GluN2A with an IC50 of 198 nM. At 10 μM, MPX-004 only weakly (up to 8%) inhibits currents in oocytes expressing GluN2B, C, or D receptors or in control oocytes[1].
MPX-004 (100 nM-30 μM; 0-50 min) causes a concentration-dependent reduction in NMDA receptor-mediated fEPSPs in region CA1 in response to Schaffer collateral stimulation in hippocampal slices prepared from brains of 3- to 4-week old rats[1].
MPX-004 (1 μM) inhibits 5-HT1B antagonist binding by 35%, 5-HT2A agonist binding by 31% and EP4 agonist binding by 27%. MPX-004 (50 μM) has no effect on AMPA receptor-mediated synaptic currents of pyramidal neurons in slices from mouse visual cortex- currents[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
-
CAS No. 1688684-07-2
-
Appearance Solid
-
Molecular Weight 455.91
-
Formula C17H15ClFN5O3S2
-
Color White to light yellow
-
SMILES
O=C(C1=NC=C(CNS(=O)(C2=CC=C(C(Cl)=C2)F)=O)N=C1)NCC3=CN=C(C)S3
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Protocols
-
Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
-
Data Sheet (267 KB)
-
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
-
Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
MPX-004 Related Classifications
HY-148939 Related Classifications
Powered by Bioz