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Cat. No.: HY-156958

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S-72

S-72 inhibits tubulin polymerization and further triggers mitosis-phase cell cycle arrest and cell apoptosis, in addition to suppressing STAT3 signaling.

For research use only. We do not sell to patients.

CAS No.: 2446799-14-8
Formula: C₂₀H₂₂N₄O₃S
Molecular Weight:398.48

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

S-72 Chemical Structure

CAS No.: 2446799-14-8

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Fluorescent Dye

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Biological Activity

Description

S-72 inhibits tubulin polymerization and further triggers mitosis-phase cell cycle arrest and cell apoptosis, in addition to suppressing STAT3 signaling^[1].

All STAT Isoforms :

Chemical Information

CAS No. 2446799-14-8
Molecular Weight 398.48
Formula C₂₀H₂₂N₄O₃S
SMILES

O=C(C1=CC=C(C)C(NS(=O)(C2=CC=C(C)C=C2)=O)=C1)NCC3=CN(C)N=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Zhenyan Hou, et al. S-72, a Novel Orally Available Tubulin Inhibitor, Overcomes Paclitaxel Resistance via Inactivation of the STING Pathway in Breast Cancer. Pharmaceuticals (Basel). 2023 May 15;16(5):749. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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S-72

PTUPB

(+)-Erinacin A

Isogarcinol

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Biological Activity

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S-72

PTUPB

(+)-Erinacin A

Isogarcinol

PDIC-NN

All STAT Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

S-72 Related Classifications

HY-156958 Related Classifications