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製品番号: HY-187734

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AY 17605

AY 17605 is a nucleoside-3':5'-monophosphate phosphodiesterase (Phosphodiesterase) inhibitor that blocks cAMP hydrolysis through non-competitive inhibition, thereby elevating intracellular cAMP levels. AY 17605 can be used in studies related to cardiotonic activity.

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CAS 番号: 7755-28-4
分子式: C₂₅H₃₆O₅
分子量:416.56

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

AY 17605 構造式

CAS 番号: 7755-28-4

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Phosphodiesterase (PDE) アイソフォーム固有の製品をすべて表示 :

体外実験

AY 17605 (preincubation 5 min; PDE reaction 1 min) is a potent non-competitive inhibitor of purified bovine heart nucleoside-3':5'-monophosphate phosphodiesterase, with an IC₅₀ of 44 μM^[1].
AY 17605 (0.1 μM; 5 min preincubation, 1.5 min PDE reaction) exhibits only weak inhibitory activity against purified rat brain nucleoside-3':5'-monophosphate phosphodiesterase^[1].
AY 17605 is a non-competitive inhibitor of bovine heart nucleoside-3':5'-monophosphate phosphodiesterase, with an IC₅₀ of 44 μM and a K_i of 0.064 μM^[2].
AY 17605 (0.1 μM) exhibits only moderate inhibitory activity against rat brain nucleoside-3':5'-monophosphate phosphodiesterase, producing 24% inhibition^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 7755-28-4
分子量 416.56
分子式 C₂₅H₃₆O₅
SMILES

O[C@@]12[C@@](C)([C@H](CC1)C=3C(=O)OCC3)CC[C@]4([C@]2(CC[C@]5([C@]4(C)CC[C@H](OC(C)=O)C5)[H])[H])[H]
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Lippmann W. Inhibition of beef heart and rat brain nucleoside-3':5'-monophosphate phosphodiesterase by 3beta-14-dihydroxy-21-oxo-23-desoxo-5-beta-card-20(22)-enolide 3-acetate (AY-17,605) and structurally related compounds. Experientia. 1974 Mar 15;30(3):237-9. [Content Brief]

[2]. Balogun RA. Amino acids in the excreta of the tsetse fly, Glossina palpalis. Experientia. 1974 Mar 15;30(3):239-40.

Calculators

モル濃度計算機

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Minimum order quantity

100 mg

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