2. MAPK/ERK Pathway
  3. Raf
  4. Uplarafenib

Uplarafenib  (Synonyms: B-Raf IN 10)

Cat. No.: HY-148059 Purity: 99.15%
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Uplarafenib (B-Raf IN 10) (Compound C09) is a BRAF inhibitor with an IC50 between 50 and 100 nM. Uplarafenib shows antitumor activity.

For research use only. We do not sell to patients.

Uplarafenib Chemical Structure

Uplarafenib Chemical Structure

CAS No. : 1425485-87-5

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Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 286 In-stock
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10 mM * 1 mL in DMSO USD 286 In-stock
Solid
5 mg USD 260 In-stock
10 mg USD 380 In-stock
25 mg USD 800 In-stock
50 mg USD 1280 In-stock
100 mg USD 2100 In-stock
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Based on 1 publication(s) in Google Scholar

Uplarafenib Related Antibodies

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Description

Uplarafenib (B-Raf IN 10) (Compound C09) is a BRAF inhibitor with an IC50 between 50 and 100 nM. Uplarafenib shows antitumor activity[1].

IC50 & Target[1]

BRAF-V600E

< 50 nM (IC50)

Braf

50-100 nM (IC50)

In Vitro

Uplarafenib (Compound C09) (1 μM) shows more than 89% inhibition against BRAF and BRAF V600E[1].
Uplarafenib shows an IC50 between 50 and 100 nM against BRAF, less than 50 nM against BRAF V600E[1].
Uplarafenib (72 h) inhibits A375 and SK-MEL-28 cells growth but not CHL-1 and SK-MEL-31 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Uplarafenib Related Antibodies

Cell Viability Assay[1]

Cell Line: A375, SK-MEL-28, SK-MEL-31 and CHL-1
Concentration:
Incubation Time: 72 h
Result: Showed inhibition with IC50s less than 500 nM against A375 and SK-MEL-28 cells, and showed no inhibition against CHL-1 and SK-MEL-31.
Molecular Weight

494.49

Formula

C22H21F3N4O4S
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(C1=C(F)C(NS(=O)(CCC)=O)=CC(F)=C1F)C2=CC=C3N=CC(N4CCOCC4)=NC3=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (202.23 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0223 mL 10.1114 mL 20.2229 mL
5 mM 0.4045 mL 2.0223 mL 4.0446 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0223 mL 10.1114 mL 20.2229 mL 50.5571 mL
5 mM 0.4045 mL 2.0223 mL 4.0446 mL 10.1114 mL
10 mM 0.2022 mL 1.0111 mL 2.0223 mL 5.0557 mL
15 mM 0.1348 mL 0.6741 mL 1.3482 mL 3.3705 mL
20 mM 0.1011 mL 0.5056 mL 1.0111 mL 2.5279 mL
25 mM 0.0809 mL 0.4045 mL 0.8089 mL 2.0223 mL
30 mM 0.0674 mL 0.3370 mL 0.6741 mL 1.6852 mL
40 mM 0.0506 mL 0.2528 mL 0.5056 mL 1.2639 mL
50 mM 0.0404 mL 0.2022 mL 0.4045 mL 1.0111 mL
60 mM 0.0337 mL 0.1685 mL 0.3370 mL 0.8426 mL
80 mM 0.0253 mL 0.1264 mL 0.2528 mL 0.6320 mL
100 mM 0.0202 mL 0.1011 mL 0.2022 mL 0.5056 mL
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Uplarafenib Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Uplarafenib1425485-87-5B-Raf IN 10RafRaf kinasesantitumorBRAF V600EA375SK-MEL-28Inhibitorinhibitorinhibit

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