2. Immunology/Inflammation NF-κB Stem Cell/Wnt MAPK/ERK Pathway Apoptosis Metabolic Enzyme/Protease
  3. NO Synthase NF-κB ERK Interleukin Related TNF Receptor Reactive Oxygen Species (ROS)
  4. Berkeleyacetal C

keleyacetal C, a meroterpenoid compound with anti-inflammatory effects via inhibiting NF-κB, ERK1/2 and IRF3 signaling pathways. Berkeleyacetal C significantly inhibits the expression of iNOS and the following NO production by macrophages. Berkeleyacetal C inhibits expression and secretion of key pro-inflammatory factors and chemokines (TNF-α, IL-6, IL-1β, MIP-1α, and MCP-1). Berkeleyacetal C also inhibits activation of neutrophils and reactive oxygen species (ROS) production. Berkeleyacetal C can be used for the study of inflammatory disorders.

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Berkeleyacetal C

Berkeleyacetal C 화학구조

CAS No. : 959772-67-9

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Berkeleyacetal C Related Antibodies

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nNOS iNOS eNOS

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NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

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ERK ERK1 ERK2 ERK5 ERK8

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TNFRSF1A/CD120a TNFRSF3/CD18 TNFRSF4 TNFRSF5/CD40 TNFRSF6/Fas/CD95 TNFRSF7/CD27 TNFRSF8/CD30 TNFRSF9/4-1BB/CD137 TNFRSF10B/DR5/CD262 TNFRSF12A/TWEAK TNFRSF16/NGF Receptor/CD271 TNFRSF18/GITR/CD357

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제품 설명

keleyacetal C, a meroterpenoid compound with anti-inflammatory effects via inhibiting NF-κB, ERK1/2 and IRF3 signaling pathways. Berkeleyacetal C significantly inhibits the expression of iNOS and the following NO production by macrophages. Berkeleyacetal C inhibits expression and secretion of key pro-inflammatory factors and chemokines (TNF-α, IL-6, IL-1β, MIP-1α, and MCP-1). Berkeleyacetal C also inhibits activation of neutrophils and reactive oxygen species (ROS) production. Berkeleyacetal C can be used for the study of inflammatory disorders[1].

IC50 & Target[1]

iNOS

 

ERK1

 

ERK2

 

NF-κB

 

IL-6

 

IL-1β

 

TNF-α

 

Cellular Effect
Cell Line Type Value Description References
BV-2 IC50
0.8 μM
Compound: 6
Antineuroinflammatory activity in human BV2 cells assessed as inhibition of LPS-induced nitric oxide production preincubated for 10 mins followed by LPS stimulation for 24 hrs by Griess assay
Antineuroinflammatory activity in human BV2 cells assessed as inhibition of LPS-induced nitric oxide production preincubated for 10 mins followed by LPS stimulation for 24 hrs by Griess assay
[PMID: 27120704]
RAW264.7 IC50
4.3 μM
Compound: 11
Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells after 24 hrs by Griess assay
Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells after 24 hrs by Griess assay
[PMID: 28960979]
분자량

442.46

화학식

C24H26O8
CAS No.
SMILES

C[C@@]12[C@](C[C@@]3([C@]4([H])[C@@]2([H])C([C@@H](O[C@]4([H])OC3=O)C)=O)C)([H])[C@]5(CO5)C(C(C(C)(O6)C)=CC1=O)=CC6=O
Structure Classification
Initial Source

fungus Penicillium purpurogenum MHZ 111
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
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Berkeleyacetal C Related Classifications

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Keywords:

Berkeleyacetal C959772-67-9NO SynthaseNF-κBERKInterleukin RelatedTNF ReceptorReactive Oxygen Species (ROS)Nitric oxide synthasesNOSNuclear factor-κBNuclear factor-kappaBExtracellular signal regulated kinasesILTumor Necrosis Factor ReceptorTNFRmeroterpenoidmacrophagesLPSanti-inflammatory effectInhibitorinhibitorinhibit

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상품명:
Berkeleyacetal C
Cat. No.:
HY-N10175
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