1. Others GPCR/G Protein Neuronal Signaling Immunology/Inflammation
  2. Isotope-Labeled Compounds Histamine Receptor
  3. Bilastine-d6

Bilastine-d6 is the deuterium labeled Bilastine. Bilastine is a selective histamine H1 receptor antagonist used for treatment of allergic rhinoconjunctivitis and urticaria[1][2].

For research use only. We do not sell to patients.

Bilastine-d<sub>6</sub> Chemical Structure

Bilastine-d6 Chemical Structure

CAS No. : 1215358-58-9

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Based on 1 publication(s) in Google Scholar

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Description

Bilastine-d6 is the deuterium labeled Bilastine. Bilastine is a selective histamine H1 receptor antagonist used for treatment of allergic rhinoconjunctivitis and urticaria[1][2].

IC50 & Target

H1 Receptor

 

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

469.65

Formula

C28H31D6N3O3

CAS No.
SMILES

CCOCCN1C(C2CCN(CC2)CCC3=CC(C(C([2H])([2H])[2H])(C([2H])([2H])[2H])C(O)=O)=CC=C3)=NC4=CC=CC=C41

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

DMSO : 10 mg/mL (21.29 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1292 mL 10.6462 mL 21.2925 mL
5 mM 0.4258 mL 2.1292 mL 4.2585 mL
View the Complete Stock Solution Preparation Table
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Purity & Documentation
References

Complete Stock Solution Preparation Table

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1292 mL 10.6462 mL 21.2925 mL 53.2311 mL
5 mM 0.4258 mL 2.1292 mL 4.2585 mL 10.6462 mL
10 mM 0.2129 mL 1.0646 mL 2.1292 mL 5.3231 mL
15 mM 0.1419 mL 0.7097 mL 1.4195 mL 3.5487 mL
20 mM 0.1065 mL 0.5323 mL 1.0646 mL 2.6616 mL
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Bilastine-d6
Cat. No.:
HY-14447S
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