Breceptin  (Synonyms: B 9870)

Breceptin (B 9870) is an antagonist of the bradykinin B₁/B₂ receptor (B₁/B₂R). Breceptin exhibits an irreversible antagonist effect on B₂R, inhibiting the vasodilation induced by Bradykinin (HY-P0206) in the rabbit carotid vein contraction experiment. B-9870 shows partial agonist properties in HEK 293 cells with high expression of B₂R, and can activate ERK1/2 phosphorylation, calcium ion mobilization, arachidonic acid release, and receptor internalization. Breceptin can be used in research to inhibit breast cancer and non-small cell lung cancer^[1].

2815.28

C₁₃₆H₂₀₀N₃₈O₂₈

215713-39-6

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Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Morissette G, et al. Antagonist, partial agonist and antiproliferative actions of B‐9870 (CU201) as a function of the expression and density of the bradykinin B1 and B2 receptors. British journal of pharmacology. 2007 Feb;150(3):369-79.  [Content Brief]