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Cat. No.: HY-100861

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C-11

C-11 is a tubulin inhibitor and acts as an ADC cytotoxin, displays cytotoxicity for carcinoma cell lines.

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CAS No.: 2007965-97-9
Formule: C₃₈H₅₈N₆O₇S
Masse moléculaire:742.97

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

C-11 Chemical Structure

CAS No.: 2007965-97-9

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Activité biologique
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Pureté et documentation
Références
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Activité biologique

Description

C-11 is a tubulin inhibitor and acts as an ADC cytotoxin, displays cytotoxicity for carcinoma cell lines^[1].

IC₅₀ & Target

Traditional Cytotoxic Agents

Voir tous les produits spécifiques à Isoform ADC Payloads :

Cellular Effect

Cell Line	Type	Value	Description	References
KB	IC₅₀	0.5 nM Compound: 11	Cytotoxicity against MDR1 deficient human KB cells assessed as decrease in cell viability after 4 days by MTS assay Cytotoxicity against MDR1 deficient human KB cells assessed as decrease in cell viability after 4 days by MTS assay	[PMID: 27882198]
MDA-MB-361	IC₅₀	0.9 nM Compound: 11	Cytotoxicity against human MDA-MB-361/DYT2 cells assessed as decrease in cell viability after 4 days by MTS assay Cytotoxicity against human MDA-MB-361/DYT2 cells assessed as decrease in cell viability after 4 days by MTS assay	[PMID: 27882198]
NCI-N87	IC₅₀	1.11 nM Compound: 11	Cytotoxicity against human NCI-N87 cells assessed as decrease in cell viability after 4 days by MTS assay Cytotoxicity against human NCI-N87 cells assessed as decrease in cell viability after 4 days by MTS assay	[PMID: 27882198]

In Vitro

C-11 exhibits cytotoxicity for N87 cells and MDA-MB-361-DYT2 cells with IC₅₀s of 1.11 nM and 0.9 nM, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2007965-97-9
Masse moléculaire 742.97
Formule C₃₈H₅₈N₆O₇S
SMILES

O=C(N(C)[C@@H](C(C)C)C[C@@H](OC(C)=O)C1=NC(C(N[C@@H](CC2=CC=C(N)C=C2)C[C@H](C)C(O)=O)=O)=CS1)[C@H]([C@@H](C)CC)NC([C@@]3(C)CCCN3C)=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Leverett CA, et al. Design, Synthesis, and Cytotoxic Evaluation of Novel Tubulysin Analogues as ADC Payloads. ACS Med Chem Lett. 2016 Aug 26;7(11):999-1004. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Activité biologique
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- IC₅₀ & Target
- In Vitro
Chemical Information
Pureté et documentation
Références

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C-11

Voir tous les produits spécifiques à Isoform ADC Payloads

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

C-11 Related Classifications

HY-100861 Related Classifications