C16 Ceramide-d7 (d18:1/16:0)
Based on 1 Customer Validation
C16-Ceramide-d7 (d18:1/16:0) is the deuterated-labeled C16-Ceramide (d18:1/16:0) (HY-100354). C16-Ceramide (d18:1/16:0) is a natural small molecule activating p53 through the direct and selective binding.
For research use only. We do not sell to patients.
- Purity : 99.0%
- CAS No.: 1840942-13-3
- Formula: C34H60D7NO3
- Molecular Weight:544.94
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Storage:
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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HY-100355S1
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C18-Ceramide-d3Stable Isotope -
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β-Galactosyl-C18-ceramide-d35Stable Isotope -
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Glucosylsphingosine-13C6Stable Isotope -
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Sphingosine (d14:1)PKC Inhibitor
All Endogenous Metabolite Isoforms
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Biological Activity
Description
IC50 & Target
In Vitro
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Application
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 1840942-13-3
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Unlabeled CAS 24696-26-2
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Appearance Solid
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Molecular Weight 544.94
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Formula C34H60D7NO3
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Color White to off-white
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SMILES
CCCCCCCCCCCCCCCC(N[C@@H](CO)[C@H](O)/C=C/CCCCCCCCCCC([2H])([2H])C([2H])([2H])C([2H])([2H])[2H])=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Solvent & Solubility
In Vitro:
DMF : 0.15 mg/mL (0.28 mM; Need ultrasonic and warming)
Purity & Documentation
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Data Sheet (268 KB)
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SDS (648 KB)
- English - EN (648 KB)
- Français - FR (648 KB)
- Deutsch - DE (648 KB)
- Norwegian - NO (648 KB)
- Español - ES (648 KB)
- Swedish - SV (648 KB)
- Italian - IT (648 KB)
- Korean - KR (648 KB)
- Portuguese - PT (648 KB)
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Handling Instructions (2659 KB)
References
[1]. Fekry B, et al. C16-ceramide is a natural regulatory ligand of p53 in cellular stress response. Nat Commun. 2018 Oct 8;9(1):4149. [Content Brief]
[2]. Rénert AF, et al. The proapoptotic C16-ceramide-dependent pathway requires the death-promoting factor Btf in colon adenocarcinoma cells. J Proteome Res. 2009 Oct;8(10):4810-22. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
C16 Ceramide-d7 (d18:1/16:0) Related Classifications
HY-116258S Related Classifications
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