CA IX-IN-6
CA IX-IN-6 is a selective human carbonic anhydrase IX (hCA IX) inhibitor, with Ki values of 8.9, 50.7, 551, and 64.4 nM against hCA IX, hCA XII, hCA I, and hCA II, respectively. CA IX-IN-6 binds to the active site via a classic sulfamide mode, coordinates with the catalytic Zn2+ ion, forms a hydrogen bond with Thr200, and interacts with key active site residues. CA IX-IN-6 can be used in studies related to tumor-associated carbonic anhydrase inhibition.
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- Formel: C18H13N3O3S
- Molecular Weight:351.38
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
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Help & FAQs
Biologische Aktivität
Beschreibung
IC50 & Target
[1]|
hCA IX 8.9 nM (Ki) |
hCA XII 50.7 nM (Ki) |
hCA I 551 nM (Ki) |
hCA II 64.4 nM (Ki) |
In Vitro
CA IX-IN-6 (compound 15h) (0.01 nM-10 mM; 15 min) potently and selectively inhibits purified human carbonic anhydrase IX with a Ki of 8.9 nM, showing 62-fold, 7-fold, and 6-fold greater selectivity over hCA I, hCA II, and hCA XII, respectively[1].
CA IX-IN-6 binds to purified human carbonic anhydrase IX via a canonical sulfonamide interaction, coordinating with the catalytic Zn2+ ion and forming a hydrogen bond with Thr200[1].
CA IX-IN-6 forms a stable complex with human carbonic anhydrase IX[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
Chemical Information
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Molecular Weight 351.38
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Formel C18H13N3O3S
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SMILES
O=S(C1=CC=C(C(/C=C/C2=CNC3=C2C=C(C#N)C=C3)=O)C=C1)(N)=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
CA IX-IN-6 Related Classifications
HY-187174 Related Classifications
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