2,4-D-d3
2,4-D-d3 is the deuterium labeled 2,4-D (HY-18572). 2,4-D (2,4-Dichlorophenoxyacetic acid) is a selective systemic herbicide for the control of broad-leaved weeds. 2,4-D acts as a plant hormone, causing uncontrolled growth in the meristematic tissues. 2,4-D inhibits DNA and protein synthesis and thereby prevents normal plant growth and development.
For research use only. We do not sell to patients.
- CAS No.: 202480-67-9
- Formula: C8H3D3Cl2O3
- Molecular Weight:224.06
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 202480-67-9
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Unlabeled Cas 94-75-7
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Appearance Solid
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Molecular Weight 224.06
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Formula C8H3D3Cl2O3
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Color White to off-white
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SMILES
OC(COC1=C(C([2H])=C(C([2H])=C1[2H])Cl)Cl)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (446.31 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
Purity & Documentation
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Data Sheet (273 KB)
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SDS (761 KB)
- English - EN (761 KB)
- Français - FR (761 KB)
- Deutsch - DE (761 KB)
- Norwegian - NO (761 KB)
- Español - ES (761 KB)
- Swedish - SV (761 KB)
- Italian - IT (761 KB)
- Portuguese - PT (761 KB)
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Handling Instructions (2659 KB)
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]
[2]. Germaine KJ, et al. Bacterial endophyte-enhanced phytoremediation of the organochlorine herbicide 2,4-dichlorophenoxyacetic acid. FEMS Microbiol Ecol. 2006 Aug;57(2):302-10. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.4631 mL | 22.3155 mL | 44.6309 mL | 111.5773 mL |
| 5 mM | 0.8926 mL | 4.4631 mL | 8.9262 mL | 22.3155 mL | |
| 10 mM | 0.4463 mL | 2.2315 mL | 4.4631 mL | 11.1577 mL | |
| 15 mM | 0.2975 mL | 1.4877 mL | 2.9754 mL | 7.4385 mL | |
| 20 mM | 0.2232 mL | 1.1158 mL | 2.2315 mL | 5.5789 mL | |
| 25 mM | 0.1785 mL | 0.8926 mL | 1.7852 mL | 4.4631 mL | |
| 30 mM | 0.1488 mL | 0.7438 mL | 1.4877 mL | 3.7192 mL | |
| 40 mM | 0.1116 mL | 0.5579 mL | 1.1158 mL | 2.7894 mL | |
| 50 mM | 0.0893 mL | 0.4463 mL | 0.8926 mL | 2.2315 mL | |
| 60 mM | 0.0744 mL | 0.3719 mL | 0.7438 mL | 1.8596 mL | |
| 80 mM | 0.0558 mL | 0.2789 mL | 0.5579 mL | 1.3947 mL | |
| 100 mM | 0.0446 mL | 0.2232 mL | 0.4463 mL | 1.1158 mL |
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