Cloprostenol
Based on 1 Customer Validation
Cloprostenol is a prostaglandin F-2α (PGF2α (HY-12956)) analogue. Cloprostenol induces luteolysis in marmoset monkeys. Cloprostenol can be used for the research of open-cervix pyometra.
For research use only. We do not sell to patients.
- Purity: 99.86%
- CAS No.: 40665-92-7
- Formula: C22H29ClO6
- Molecular Weight:424.92
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Adult Female Common marmoset monkeys (250-510 g, regular ovarian cycles)[1]
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Dosage:0.5 μg
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Administration:i.m.; single injection
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Result:Failed to induce luteolysis in animals treated on Days 6 or 7 of the ovarian cycle, with progesterone concentrations remaining elevated until at least Day 15-16 post-injection.
Induced luteolysis in 3/5 animals treated on Day 8.
Induced luteolysis in 1/2 animals treated on Day 9.
Induced complete, irreversible luteolysis within 24 hours in all 23 animals treated between Days 10 and 17, with progesterone falling to <10 ng/mL and remaining at this level until the day after post-treatment ovulation.
Resulted in a mean interval from injection to ovulation of 10.7 days for treatments between Days 8 and 17 where permanent luteolysis occurred, with no significant difference between mid-luteal and late luteal phase treatments, or between females paired with vasectomized versus intact males.
Produced post-treatment ovarian cycles with a normal mean length of 27.6 days and luteal phase of 18.7 days in 7 animals monitored.
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Animal Model:Adult Female Common marmoset monkeys (range 250-510 g, pregnant between Days 19 and 43)[1]
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Dosage:0.5 μg
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Administration:i.m.; single injection
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Result:Induced complete luteolysis within 24 hours in all 7 pregnant animals, with progesterone falling to <10 ng/mL and remaining at this level until the day after post-treatment ovulation.
Resulted in a mean interval from injection to ovulation of 10.9 days.
Produced 23 morphologically normal embryos out of 24 collected 6-9 days post-treatment from 11 animals, with 1 degenerate morula.
Chemical Information
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CAS No. 40665-92-7
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Appearance Solid
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Molecular Weight 424.92
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Formula C22H29ClO6
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Color White to off-white
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SMILES
OC(CCC/C=C\C[C@H]1[C@@H]([C@@H](O)C[C@H]1O)/C=C/[C@H](O)COC2=CC(Cl)=CC=C2)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (268 KB)
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SDS (392 KB)
- English - EN (392 KB)
- Français - FR (392 KB)
- Deutsch - DE (392 KB)
- Norwegian - NO (392 KB)
- Español - ES (392 KB)
- Swedish - SV (392 KB)
- Italian - IT (392 KB)
- Korean - KR (392 KB)
- Portuguese - PT (392 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Cloprostenol Related Classifications
HY-121314 Related Classifications
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