CP-664511
CP-664511 is an orally active and potent α4β1 integrin antagonist with anti-inflammatory effects (IC50=0.52 nM). CP-664511 inhibits the interaction between α4β1 and vascular cell adhesion molecule-1 (VCAM-1), significantly reducing eosinophil infiltration into lung tissue. CP-664511 is promising for research of asthma and allergic airway diseases.
For research use only. We do not sell to patients.
- CAS No.: 379692-00-9
- Formula: C28H34N4O6
- Molecular Weight:522.59
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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α4β1 0.52 nM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Jurkat | IC50 |
0.69 nM
Compound: 22
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Inhibition of Alpha4-beta1 integrin in Jurkat cells
Inhibition of Alpha4-beta1 integrin in Jurkat cells
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[PMID: 11551757] |
Chemical Information
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CAS No. 379692-00-9
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Molecular Weight 522.59
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Formula C28H34N4O6
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SMILES
O=C(O)CCC1=CC([C@@H](NC(CC2=CC=C(NC(NC3=CC=CC=C3C)=O)C(OC)=C2)=O)CC(C)C)=NO1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CP-664511 Related Classifications
HY-119142 Related Classifications
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