Elranatamab
Based on 1 Customer Validation
Elranatamab (PF-06863135) is an anti-CD3E/TNFRSF17 human IgG2κ monoclonal antibody. Recommend Isotype Controls: Human IgG2 kappa, Isotype Control (HY-P99002).
For research use only. We do not sell to patients.
- Purity : 98.74%
- CAS No.: 2408850-14-4
- Molecular Weight:145.441 kDa
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Storage:Shipping with dry ice
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
Description
Isotype
Human IgG2 kappa
Recommend Isotype Controls
Species Reactivity
Human
IC50 & Target
CD3E & TNFRSF17
In Vitro
Elranatamab (0.1-10 nM, 2 days) exhibits cytotoxicity in L-363 myeloma cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:L-363
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Concentration:0.1-10 nM
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Incubation Time:2 days
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Result:Exhibited cytotoxicity
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | 2011-05 | PHASE1 |
Gene ID
Accession
Conjugated
Unconjugated
Reconsititution
The product can be reconstituted/diluted with sterile PBS or saline.
Format
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Human IgG2 kappa
Application
ELISA, FACS, Functional assay
Verified Bioactivity
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Loaded BCMA/TNFRSF17 Trimer Protein, Human (Biotinylated, HEK293, His-Avi, HY-P78071) on NTA biosensor, can bind Elranatamab with an affinity constant of 2.432E-11 M as determined in BLI assay. -
Flow cytometric analysis of 1×106 Jurkat cells labelling CD3E (red) with Elranatamab (HY-P99909). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG2 kappa Isotype Control (HY-P99002, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).
Chemical Information
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CAS No. 2408850-14-4
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Appearance Liquid
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Molecular Weight 145.441 kDa
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Color Colorless to light yellow
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SMILES
[Elranatamab]
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Synonyms
PF-06863135; RN-613
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Shipping
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (254 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
[1]. Elranatamab
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)