Cat. No.: HY-164385

NSC126405

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Based on 1 Customer Validation

NSC126405 is a mTOR-DEPTOR inhibitor that binds to DEPTOR, prevents mTOR-DEPTOR binding and induces multiple myeloma (MM) cytotoxicity. NSC126405 can be utilized in cancer research.

For research use only. We do not sell to patients.

Purity: 99.20%
CAS No.: 17581-52-1
Formula: C₅H₂Cl₄N₂
Molecular Weight:231.89

Storage:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

NSC126405 Chemical Structure

CAS No.: 17581-52-1

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

NSC126405 is a mTOR-DEPTOR inhibitor that binds to DEPTOR, prevents mTOR-DEPTOR binding and induces multiple myeloma (MM) cytotoxicity. NSC126405 can be utilized in cancer research^[1].

All mTOR Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
MM1.S	IC₅₀	3 μM Compound: B; NSC126405	Cytotoxicity against human MM1S cells after 48 hrs by MTT assay Cytotoxicity against human MM1S cells after 48 hrs by MTT assay	[PMID: 28916338]
PBL	IC₅₀	20 μM Compound: B; NSC126405	Cytotoxicity against PBL (unknown origin) after 48 hrs by MTT assay Cytotoxicity against PBL (unknown origin) after 48 hrs by MTT assay	[PMID: 28916338]
RPMI-8226	IC₅₀	1.3 μM Compound: B; NSC126405	Cytotoxicity against human RPMI8226 cells after 48 hrs by MTT assay Cytotoxicity against human RPMI8226 cells after 48 hrs by MTT assay	[PMID: 28916338]

Chemical Information

CAS No. 17581-52-1
Appearance Solid
Molecular Weight 231.89
Formula C₅H₂Cl₄N₂
Color Orange to red
SMILES

ClC(C(Cl)=C/1Cl)=C(Cl)C1=N\N
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (431.24 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

4.3124 mL

21.5619 mL

43.1239 mL

5 mM

0.8625 mL

4.3124 mL

8.6248 mL

10 mM

0.4312 mL

2.1562 mL

4.3124 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Dilution Calculator

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Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (275 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Shi Y, et al. Cytotoxic Properties of a DEPTOR-mTOR Inhibitor in Multiple Myeloma Cells. Cancer Res. 2016 Oct 1;76(19):5822-5831. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	4.3124 mL	21.5619 mL	43.1239 mL	107.8097 mL
	5 mM	0.8625 mL	4.3124 mL	8.6248 mL	21.5619 mL
	10 mM	0.4312 mL	2.1562 mL	4.3124 mL	10.7810 mL
	15 mM	0.2875 mL	1.4375 mL	2.8749 mL	7.1873 mL
	20 mM	0.2156 mL	1.0781 mL	2.1562 mL	5.3905 mL
	25 mM	0.1725 mL	0.8625 mL	1.7250 mL	4.3124 mL
	30 mM	0.1437 mL	0.7187 mL	1.4375 mL	3.5937 mL
	40 mM	0.1078 mL	0.5390 mL	1.0781 mL	2.6952 mL
	50 mM	0.0862 mL	0.4312 mL	0.8625 mL	2.1562 mL
	60 mM	0.0719 mL	0.3594 mL	0.7187 mL	1.7968 mL
	80 mM	0.0539 mL	0.2695 mL	0.5390 mL	1.3476 mL
	100 mM	0.0431 mL	0.2156 mL	0.4312 mL	1.0781 mL

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NSC126405

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All mTOR Isoforms

Biological Activity

Chemical Information

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

NSC126405 Related Classifications

HY-164385 Related Classifications