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Cat. No.: HY-184063

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Vexicitinib

(Synonyms: Vexicitinibum)

Vexicitinib (Vexicitinibum) is a SYK and JAK2 inhibitor with IC₅₀ values both less than 10 nM. Vexicitinib exhibits anti-inflammatory and immunosuppressive effects. Vexicitinib can be used in tumor-related research.

For research use only. We do not sell to patients.

CAS No.: 2230362-69-1
Formula: C₂₂H₂₇N₇O₄S
Molecular Weight:485.56

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Vexicitinib Chemical Structure

CAS No.: 2230362-69-1

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- Parmacokinetics
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target^[2]

JAK2

<10 nM (IC₅₀)

Syk

<10 nM (IC₅₀)

All JAK Isoforms :

In Vitro

Vexicitinib (Compound C10R) potently inhibits purified SYK protein kinase activity with an IC₅₀ of <10 nM^[2].
Vexicitinib potently inhibits purified JAK2 protein kinase activity with an IC₅₀ of <10 nM^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parmacokinetics

Species	Dose	Route	T_max	T_1/2	C_max	AUC_0-24
Mice^[2]	5 mg/kg	p.o.	0.5 h	2.41 h	451.36 ng/mL	1243.51 ng/mL·h

Chemical Information

CAS No. 2230362-69-1
Molecular Weight 485.56
Formula C₂₂H₂₇N₇O₄S
SMILES

O=S(N1C[C@@]2([H])N(CC1)C3=CC=C(NC4=NC=C(C(N)=O)C(NC5CC5)=N4)C=C3OC2)(C6CC6)=O
Synonyms

Vexicitinibum
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. International Nonproprietary
Names for Pharmaceutical
Substances (INN). WHO Drug Information, Vol. 39, No. 4, 2025.

[2]. Zhang, et al. Compound containing tricyclic heteroaryl group. WO2018108084A1. WIPO (PCT). 2017-12-12.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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Vexicitinib

All JAK Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Vexicitinib Related Classifications

HY-184063 Related Classifications