12-OAHSA
Based on 1 Customer Validation
12-OAHSA is a component of olive oil. 12-OAHSA has oral activity, and improves glucose homeostasis in insulin resistant obese mice.
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- Pureté : 99.0%
- CAS No.: 101901-73-9
- Formule: C36H68O4
- Masse moléculaire:564.92
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Stockage:
Solution, -20°C, 2 years
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Activité biologique
Description
In Vitro
12-OAHSA (25 μM, 24 h) inhibits LPS-induced IL-1b, IL-6, Nos2, and Tnf-α in Raw 264.7 macrophages[1].
12-OAHSA (25 μM, 6 h) reduces IKKβ phosphorylation and increases phosphorylation of p65 in Raw 264.7 macrophages[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:10-week HFD induced obese C57BL/6 mice[1]
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Dosage:30 mg/kg
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Administration:p.o., for 10 d
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Result:Decreased adipose tissue macrophage (ATMs), and CD4+ and CD8+ T lymphocytes in eWAT.
Inhibits obesity-induced adipose tissue inflammation.
Chemical Information
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CAS No. 101901-73-9
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Appearance Liquid
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Masse moléculaire 564.92
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Formule C36H68O4
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Color Colorless to light yellow
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SMILES
CCCCCCCC/C=C\CCCCCCCC(OC(CCCCCC)CCCCCCCCCCC(O)=O)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Solution, -20°C, 2 years
Pureté et documentation
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Fiche technique (264 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instruction de manipulation (2659 KB)
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)