123B9
Based on 1 publication(s) in Google Scholar
123B9, a tumor-homing agent, is a potent and selective EphA2 agonist with a Kd value of 4.0 μM. 123B9 selectively targets the EphA2 tyrosine kinase receptor ligand-binding domain. 123B9 does not appreciably inhibit the ligand binding domains of the most closely related EphA3 and EphA4 receptors.
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- Pureté: 99.67%
- CAS No.: 2225868-19-7
- Formule: C58H82ClFN12O20
- Masse moléculaire:1321.79
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Stockage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
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Protein Tyrosine Kinase Compound Library
HY-L016
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Anti-Cancer Compound Library
HY-L025
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Angiogenesis-Related Compound Library
HY-L088
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Peptide Library
HY-L105
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Membrane Protein-targeted Compound Library
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Membrane Receptor-targeted Compound Library
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Highly Selective Activators Library
HY-L159
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Bioactive Compound Library Max
HY-L181
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Peptide Compound Library
HY-L105S
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Bioactive Compound Library
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Protein Kinase Compound Library
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Cell Proliferation Compound Library
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High-Throughput Bioactive Compound Library
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Publications Citing Use of MedChemExpress (MCE) 123B9
More
Activité biologique
Kd: 4.0 μM (EphA2)[1]
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2225868-19-7
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Appearance Solid
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Masse moléculaire 1321.79
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Formule C58H82ClFN12O20
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Color White to off-white
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Sequence
{2-(3-chloro-4-fluorophenoxy)acetic acid}-Ser-Ala-Tyr-Pro-Asp-Ser-Val-Pro-{Nle}-{Hsr}-Ser-NH2
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Sequence Shortening
{2-(3-chloro-4-fluorophenoxy)acetic acid}-SAYPDSVP-{Nle}-{Hsr}-S-NH2
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (1)
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Journal Impact Factor
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Most Recent
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Eur J Med Chem
Targeting both wild-type EGFR and its drug-resistant mutants with erlotinib-aptamer conjugates. [Abstract]2025 Jun 14:296:117871. PMID: 40554308
Solvant et solubilité
DMSO : 100 mg/mL (75.65 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (280 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.7565 mL | 3.7827 mL | 7.5655 mL | 18.9137 mL |
| 5 mM | 0.1513 mL | 0.7565 mL | 1.5131 mL | 3.7827 mL | |
| 10 mM | 0.0757 mL | 0.3783 mL | 0.7565 mL | 1.8914 mL | |
| 15 mM | 0.0504 mL | 0.2522 mL | 0.5044 mL | 1.2609 mL | |
| 20 mM | 0.0378 mL | 0.1891 mL | 0.3783 mL | 0.9457 mL | |
| 25 mM | 0.0303 mL | 0.1513 mL | 0.3026 mL | 0.7565 mL | |
| 30 mM | 0.0252 mL | 0.1261 mL | 0.2522 mL | 0.6305 mL | |
| 40 mM | 0.0189 mL | 0.0946 mL | 0.1891 mL | 0.4728 mL | |
| 50 mM | 0.0151 mL | 0.0757 mL | 0.1513 mL | 0.3783 mL | |
| 60 mM | 0.0126 mL | 0.0630 mL | 0.1261 mL | 0.3152 mL |
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