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United States

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Cat. No.: HY-P10386

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155H1

155H1 (Compound 11) is a stapled peptide, that covalently binds hMcl1 (172-323) with IC₅₀ of 18 nM.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

Formule: C₇₉H₁₂₀FN₁₉O₂₃S
Masse moléculaire:1754.98

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

155H1 Chemical Structure

Stock

Quantité

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique

Description

155H1 (Compound 11) is a stapled peptide, that covalently binds hMcl1 (172-323) with IC₅₀ of 18 nM^[1].

Voir tous les produits spécifiques à Isoform Bcl-2 Family :

Chemical Information

Masse moléculaire 1754.98
Formule C₇₉H₁₂₀FN₁₉O₂₃S
Sequence

Ac-{Dap(2MeO,5FSB)}-Ile-Ala-Glu-Gln-Leu-Arg-{(S)-2-(4-pentenyl)Ala}-Ile-Gly-Asp-{(S)-2-(4-pentenyl)Ala}-Phe-CONH2 (2MeO,5FSB=2-methoxy, 5-sulfonyl fluoride)
Sequence Shortening

Ac-{Dap(2MeO,5FSB)}-IAEQLR-{(S)-2-(4-pentenyl)Ala}-IGD-{(S)-2-(4-pentenyl)Ala}-F-CONH2 (2MeO,5FSB=2-methoxy, 5-sulfonyl fluoride)
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocole

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (259 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Alboreggia G, et al., Histidine-Covalent Stapled Alpha-Helical Peptides Targeting hMcl-1. J Med Chem. 2024 May 23;67(10):8172-8185. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Keywords

MOQ

Minimum order quantity

100 mg

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