308-R
308-R is a SGK3/SGK1/S6K1 inhibitor. 308-R exhibits an IC50 of 5 nM against human SGK3, an IC50 of 10 nM against human SGK1, and an IC50 of 1 nM against human S6K1. 308-R can be used in breast cancer research. It is also applicable to studies related to PROTAC synthesis, such as serving as the target protein ligand for PROTAC SGK3 degrader-2 (HY-176823).
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- CAS No.: 2376724-98-8
- Formule: C23H23FN6O4S
- Masse moléculaire:498.53
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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SGK3 5 nM (IC50) |
SGK1 10 nM (IC50) |
S6K1 1 nM (IC50) |
308-R potently inhibits SGK3, SGK1, and S6K1 kinases in vitro with IC50 values of 5 nM, 10 nM, and 1 nM, respectively[1].
308-R (1 μM; 8 h) potently suppresses NDRG1 Thr346 phosphorylation in HEK293 cells when combined with Akt inhibition, while 308-R (1 μM; 8 h) has minimal effect under basal conditions[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HEK293 cells
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Concentration:1 μM (basal conditions); 1 μM (combination with Akt inhibition)
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Incubation Time:8 h (basal conditions); 8 h (combination with Akt inhibition)
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Result:Exerted minimal effect on phosphorylation of NDRG1 at Thr346 under basal conditions without Akt inhibition.
Markedly suppressed phosphorylation of NDRG1 at Thr346 in the presence of Akt inhibition.
Chemical Information
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CAS No. 2376724-98-8
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Masse moléculaire 498.53
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Formule C23H23FN6O4S
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SMILES
CC1=CC=C(C(S(=O)(NC2=CC=C(C=C2)C3=NC(OC[C@H]4CNCCO4)=C5C=NNC5=N3)=O)=C1)F
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
308-R Related Classifications
HY-151009 Related Classifications
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