8-Hydroxyefavirenz
Based on 1 Customer Validation
8-Hydroxyefavirenz (8-OH-EFV) is a primary metabolite of (HY-10572). 8-Hydroxyefavirenz induces apoptosis via a JNK- and BimEL-dependent mechanism in primary human hepatocytes. 8-Hydroxyefavirenz can be used in research of cancer. 8-Hydroxyefavirenz is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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- Pureté: 97.01%
- CAS No.: 205754-33-2
- Formule: C14H9ClF3NO3
- Masse moléculaire:331.67
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Stockage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
Description
In Vitro
8-Hydroxyefavirenz (8-OH-EFV; 1-10 μM; 3-24 h; primary human hepatocytes) increases cell death in a time- and concentration-dependent manner and induces caspase-3 activity beginning at 6 h[1].
8-Hydroxyefavirenz (1-10 μM; 6-24 h) stimulates mitochondria ROS production in primary human hepatocytes[1].
8-Hydroxyefavirenz (10 μM; 3-24 h) activates JNK and increases the ratio of phosphorylated JNK to total JNK by 4.2-fold. 8-Hydroxyefavirenz increases the mRNA and protein expression of BimEL[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Primary human hepatocytes
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Concentration:1 and 10 μM
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Incubation Time:3, 6, 12 and 24 hours
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Result:Increased cell death in a time- and concentration-dependent manner and increased cell death by 3.4-fold at 6 h.
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Cell Line:Primary human hepatocytes
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Concentration:1 and 10 μM
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Incubation Time:3, 6, 12 and 24 hours
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Result:Increased the expression of cleaved caspase-3 in a time- and concentration-dependent manner.
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Cell Line:Primary human hepatocytes
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Concentration:1 and 10 μM
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Incubation Time:3, 6, 12 and 24 hours
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Result:Increased the phosphorylation of JNK and increased the mRNA and protein expression of BimEL.
Chemical Information
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CAS No. 205754-33-2
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Appearance Solid
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Masse moléculaire 331.67
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Formule C14H9ClF3NO3
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Color White to off-white
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SMILES
O=C1NC2=C(O)C=C(Cl)C=C2[C@](C(F)(F)F)(C#CC3CC3)O1
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Synonyms
8-OH-EFV
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvant et solubilité
In Vitro:
DMSO : 250 mg/mL (753.76 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (279 KB)
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SDS (761 KB)
- English - EN (761 KB)
- Français - FR (761 KB)
- Deutsch - DE (761 KB)
- Norwegian - NO (761 KB)
- Español - ES (761 KB)
- Swedish - SV (761 KB)
- Italian - IT (761 KB)
- Korean - KR (761 KB)
- Portuguese - PT (761 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.0150 mL | 15.0752 mL | 30.1504 mL | 75.3761 mL |
| 5 mM | 0.6030 mL | 3.0150 mL | 6.0301 mL | 15.0752 mL | |
| 10 mM | 0.3015 mL | 1.5075 mL | 3.0150 mL | 7.5376 mL | |
| 15 mM | 0.2010 mL | 1.0050 mL | 2.0100 mL | 5.0251 mL | |
| 20 mM | 0.1508 mL | 0.7538 mL | 1.5075 mL | 3.7688 mL | |
| 25 mM | 0.1206 mL | 0.6030 mL | 1.2060 mL | 3.0150 mL | |
| 30 mM | 0.1005 mL | 0.5025 mL | 1.0050 mL | 2.5125 mL | |
| 40 mM | 0.0754 mL | 0.3769 mL | 0.7538 mL | 1.8844 mL | |
| 50 mM | 0.0603 mL | 0.3015 mL | 0.6030 mL | 1.5075 mL | |
| 60 mM | 0.0503 mL | 0.2513 mL | 0.5025 mL | 1.2563 mL | |
| 80 mM | 0.0377 mL | 0.1884 mL | 0.3769 mL | 0.9422 mL | |
| 100 mM | 0.0302 mL | 0.1508 mL | 0.3015 mL | 0.7538 mL |
8-Hydroxyefavirenz Related Classifications
HY-137397 Related Classifications
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