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C-176

125 Cited Publications
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Based on 125 publication(s) in Google Scholar

C-176 is a selective and blood-brain barrier permeable STING inhibitor. C-176 covalently targets transmembrane cysteine residue 91 and thereby blocking activation-induced palmitoylation of STING.

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  • Pureté: 98.47%
  • CAS No.: 314054-00-7
  • Formule: C11H7IN2O4
  • Masse moléculaire:358.09
  • Stockage:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 2 years , -20°C, 1 year
  • C-176 Chemical Structure
    C-176 Chemical Structure
  • Experimental Validation Results for C-176
  • Experimental Validation Results for C-176
  • Experimental Validation Results for C-176
CAS No.: 314054-00-7
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  • C-176 Chemical Structure
    C-176 Chemical Structure
    1/16
  • 1/16

    C-176 purchased from MedChemExpress. Usage Cited in: J Neuroinflammation. 2020 May 25;17(1):165. [Abstract]

    Customer Validation
     Western blotting indicated that the level of TBK1 phosphorylation is significantly increased after SAH. Compared with SAH + vehicle group, the phosphorylation of TBK1 is remarkably inhibited by C-176.

  • 1/16

    C-176 purchased from MedChemExpress. Usage Cited in: Aging Cell. 2020 Aug;19(8):e13186. [Abstract]

    Customer Validation
     The BMDMs from the young and aged mice are pretreated with C-176 (20 µM) or STING siRNA followed by stimulation with mtDNA (100 ng/ml). The C-176 treatment effectively inhibits STING activation in both young and aged BMDMs post-mtDNA stimulation, as shown by the decreased protein levels of P-STING and P-TBK1.

  • 1/16

    C-176 purchased from MedChemExpress. Usage Cited in: Aging Cell. 2020 Aug;19(8):e13186. [Abstract]

    Customer Validation
     The BMDMs from the young and aged mice are pretreated with C-176 (20 µM) or STING siRNA followed by stimulation with mtDNA (100 ng/ml). STING inhibition by C-176 blocks the over-activation of NLRP3 signaling in the BMDMs from the young and aged mice post-mtDNA stimulation, as shown by decreased levels of NLRP3 and Cleaved caspase-1 expression.

  • C-176