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Pyridostatin

(Synonyms: RR82)
34 Cited Publications
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Based on 34 publication(s) in Google Scholar

Pyridostatin (RR82) is a G-quadruplex DNA stabilizing agent (Kd=490 nM) and can target DNA and RNA G4s in cells. Pyridostatin promotes growth arrest in human cancer cells by inducing replication- and transcription-dependent DNA damage. Pyridostatin targets the proto-oncogene Src. Pyridostatin reduced SRC protein levels and SRC-dependent cellular motility in human breast cancer cells.

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  • Pureté: 96.03%
  • CAS No.: 1085412-37-8
  • Formule: C31H32N8O5
  • Masse moléculaire:596.64
  • Stockage:
    Powder   -20°C, 3 years ; In solvent   -80°C, 6 months , -20°C, 1 month
  • Pyridostatin Chemical Structure
    Pyridostatin Chemical Structure
  • Experimental Validation Results for Pyridostatin
  • Experimental Validation Results for Pyridostatin
  • Experimental Validation Results for Pyridostatin
  • Experimental Validation Results for Pyridostatin
  • Experimental Validation Results for Pyridostatin
CAS No.: 1085412-37-8
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Cell Proliferation/Viability AssayRT-PCRWBHistological Imaging/Staining
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  • Pyridostatin Chemical Structure
    Pyridostatin Chemical Structure
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    Pyridostatin purchased from MedChemExpress. Usage Cited in: Nat Commun. 2022 Sep 16;13(1):5456. [Abstract]

    Customer Validation
     Stacked bar graphs of zebrafish embryos in dead, deformd, and normal status with different G4 stabilizer (Pyridostatin hydrochloride, 0.05-20 ng/μL, 5 nL) concentration at 24 hpf (d) and 48 hpf (e).

  • 1/16

    Pyridostatin purchased from MedChemExpress. Usage Cited in: Nat Commun. 2022 Sep 16;13(1):5456. [Abstract]

    Customer Validation
     qRT-PCR measurement of shox. The mRNA expression level of the shoxgene was detected at different time points (3, 7, and 14 days post-fertilization; i.e., 3 dpf, 7 dpf, and 14 dpf). The results showed that, compared with wild-type zebrafish, the G4 stabilizer Pyridostatin hydrochloride (0.05-0.1 ng/μL) significantly reduced the shox mRNA expression level in wrn−/− zebrafish.

  • 1/16

    Pyridostatin purchased from MedChemExpress. Usage Cited in: J Hepatol. 2020 Aug;73(2):371-382. [Abstract]

    Customer Validation
     Levels of miR-26a in MPHs transfected with miR-26a-WT or miR-26a-G4mut plasmids and stimulated with Pyridostatin hydrochloride (PDS, 10 μM; 48 h). The results showed that PDS significantly diminished the increase in miR-26a expression induced by miR-26a-WT plasmids, but not by miR-26a-G4mut plasmids, indicating that the G/A mutations are sufficient to abolish the inhibitory effect of PDS on miR-26a expression.

  • 1/16

    Pyridostatin purchased from MedChemExpress. Usage Cited in: J Hepatol. 2020 Aug;73(2):371-382. [Abstract]

    Customer Validation
     Pyridostatin hydrochloride (PDS, 10 μM; 48 h) markedly inhibited insulin-induced AKT activation, a central hallmark of insulin sensitivity, in MPHs (isolated from C57BL/6 mice) transfected with miR-26a-WT plasmids.

  • 1/16

    Pyridostatin purchased from MedChemExpress. Usage Cited in: J Hepatol. 2020 Aug;73(2):371-382. [Abstract]

    Customer Validation
     8- to 10-week-old mice were infused with Pyridostatin hydrochloride (PDS, 6 mg/kg body weight) or saline (NC) via caudal vein twice a day (n = 5). 12 h post the second injection, the following measurements were performed. Representative H&E staining of paraffin liver sections. Scale bars: 20 μm. The results showed that no significant differences in histology and morphology were observed between PDS-treated mice and saline-treated mice.

  • Pyridostatin