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Cat. No.: HY-N14664

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Actithiazic acid

(Synonyms: Mycobacidin; Cinnamonin; Acidomycin)

Actithiazic acid is a thiazolidinone antibiotic that targets biotin synthase. Actithiazic acid interferes with essential bacterial metabolism by inhibiting the final step of biotin synthesis (conversion of desthiobiotin to biotin, IC₅₀ = 0.45 μM). Actithiazic acid can be used in studies related to mycobacterial infections.

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CAS No.: 539-35-5
Formule: C₉H₁₅NO₃S
Masse moléculaire:217.29

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

Actithiazic acid Chemical Structure

CAS No.: 539-35-5

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Activité biologique
- Description
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Bioz

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Description

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In Vitro

Actithiazic acid (0.45-3.9 μM; 20 min) inhibits the enzymatic conversion of desthiobiotin to biotin in resting cell suspensions of Escherichia coli K-12 strain ABD313-136, with an IC₅₀ of 0.45 μM^[1].
Actithiazic acid (1 μg/mL) induces derepression of the biotin A operon in Escherichia coli K-12 strain Y10-1, with the maximum enhancement of 7,8-diaminopelargonic acid aminotransferase and desthiobiotin synthetase activities observed at the concentration of 1 μg/mL^[1].
Actithiazic acid promotes the excretion of biotin-like substances in growth cultures of Escherichia coli and various other microorganisms^[1].
Combination of actithiazic acid (10-50 μg/mL; 18 h) with Cephalexin (HY-B0200) exerts moderate synergistic effects against *Escherichia coli* 9632 in nutrient broth^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 539-35-5
Masse moléculaire 217.29
Formule C₉H₁₅NO₃S
SMILES

O=C(CCCCCC1SCC(N1)=O)O
Synonyms

Mycobacidin; Cinnamonin; Acidomycin
Structure Classification
- Antibiotics
- Other Antibiotics
Initial Source
- Microorganisms
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Eisenberg MA, et al. Mode of action of the biotin antimetabolites actithiazic acid and alpha-methyldethiobiotin. Antimicrob Agents Chemother. 1982;21(1):5-10. [Content Brief]

[2]. Nadkarni SR, et al. In vitro synergy of actithiazic acid, an antimetabolite of biotin, combined with cephalexin. The Journal of Antibiotics. 1983;36(11):1567-8.

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Actithiazic acid

Voir tous les produits spécifiques à Isoform Antibiotic

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

Actithiazic acid Related Classifications

HY-N14664 Related Classifications