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Cat. No.: HY-P3212A

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Allo-aca TFA

Name: Allo-aca TFA
Brand: MedChemExpress
SKU: HY-P3212A
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10 Cited Publications

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Based on 10 publication(s) in Google Scholar

Allo-aca TFA, a leptin peptidomimetic, is a potent, specific leptin receptor antagonist peptide. Allo-aca TFA blocks leptin signaling and action in numerous in vitro and in vivo models.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

Formule: C₅₀H₇₆F₃N₁₃O₁₇
Masse moléculaire:1188.21

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Please store the product under the recommended conditions in the Certificate of Analysis.

Allo-aca TFA Chemical Structure

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- In Vitro
- In Vivo
Chemical Information
Publications (10)
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

Allo-aca TFA, a leptin peptidomimetic, is a potent, specific leptin receptor antagonist peptide. Allo-aca TFA blocks leptin signaling and action in numerous in vitro and in vivo models^[1]^[2].

Voir tous les produits spécifiques à Isoform Neuropeptide Y Receptor :

In Vitro

Allo-aca TFA inhibits leptin-induced proliferation of MDA-MB-231 cells at 50 pM concentration. Allo-aca TFA inhibits leptin-induced proliferation of MCF-7 cells with an IC₅₀ of 200 pM^[1].
Allo-aca TFA at 250 nmol/L reduces VEGF-dependent leptin mRNA expression in both cell lines below base levels. Allo-aca TFA inhibits VEGF mitogenic effects. Allo-aca TFA inhibits VEGF-induced chemotaxis and chemokinesis in RF/6A retinal endothelial cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

In an MDA-MB-231 orthotopic mouse xenograft model, Allo-aca TFA administered subcutaneously significantly extends the average survival time from 15.4 days (untreated controls) to 24 and 28.1 days at 0.1 and 1mg/kg/day doses, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Masse moléculaire 1188.21
Formule C₅₀H₇₆F₃N₁₃O₁₇
Sequence Shortening

{H-allo}-TE-{Nva}-VALSR-{Aca}-NH2
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (10)

All Histological Imaging/StainingFlow CytometryIn Vivo Efficacy StudyWBCell Proliferation/Viability AssayBio/Physico-chemical Assay

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Cancer Cell

Chemotherapy triggers immune evasion by fostering LEPR+ Kupffer cell differentiation in liver metastases. [Abstract]

2026 Mar 9;44(3):658-675.e12. PMID: 41687606

Allo-aca TFA purchased from MedChemExpress. Usage Cited in: Cancer Cell. 2026 Mar 9;44(3):658-675.e12. [Abstract]

KMplots and BLI analysis of the mice received chemotherapy along with Veh. or Allo-aca (1 mg/kg; i.p.; every two days) (n = 8 mice/group).
Cell Death Dis

Marrow leptin-LEPR signaling rewires mitochondrial oxidative metabolism to confer chemoresistance in acute myeloid leukemia. [Abstract]

2026 Feb 23;17(1):249. PMID: 41730833

Allo-aca TFA purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2026 Feb 23;17(1):249. [Abstract]

Allo-aca (1 mg/kg; i.p.; once daily from days 11 to 20). Kaplan-Meier survival curve of MLL-AF9 AML mice (n = 5 mice per group).

Allo-aca TFA purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2026 Feb 23;17(1):249. [Abstract]

Representative H&E-stained sections of BM, spleen and liver (scale bars: 20 μm). The results showed that leptin (Allo-aca) (1 mg/kg; i.p.; once daily from days 11 to 20) dampened Ara-C cytotoxicity, extensive leukemic infiltration of liver and spleen.

Allo-aca TFA purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2026 Feb 23;17(1):249. [Abstract]

Allo-aca (1 mg/kg; i.p.; once daily from days 11 to 20). Representative FCM profiles (left) and quantification of YFP⁺ AML cells in BM, spleen, and liver of MLL-AF9 AML mice (n = 5 mice per group).

Allo-aca TFA purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2026 Feb 23;17(1):249. [Abstract]

Western blot analysis of LEPR expression in AML cells under indicated treatments (Allo-aca (1 mg/kg; i.p.; once daily from days 11 to 20), ect.). β-actin served as the loading control.

Allo-aca TFA purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2026 Feb 23;17(1):249. [Abstract]

Effect of Allo-aca on AML cell chemosensitivity by CCK-8 assay. The inhibition rates were calculated from eight treatment arms: (i) PBS; (ii) Allo-aca (1 mg/kg; i.p.; once daily from days 11 to 20) alone; (iii) Leptin alone; (iv) Allo-aca + Leptin; (v) Ara-C alone (or DNR); (vi) Allo-aca + Ara-C (or DNR); (vii) Leptin + Ara-C (or DNR) and (viii) Allo-aca + Leptin + Ara-C (or DNR).

Allo-aca TFA purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2026 Feb 23;17(1):249. [Abstract]

Allo-aca (1 mg/kg; i.p.; once daily from days 11 to 20). Mitochondrial respiration analysis of sorted MLL-AF9 AML cells using Seahorse XF technology (n = 5 mice per group).
Stem Cell Res Ther

Modulation of senescent Lepr+ skeletal stem cells via suppression of leptin-induced STAT3‒FGF7 axis activation alleviates abnormal subchondral bone remodeling and osteoarthritis progression. [Abstract]

2025 May 5;16(1):227. PMID: 40325465
Int J Mol Sci

Cinnamaldehyde Inhibits Leptin-Induced MMP-1 by Modulating Leptin Receptor/STAT3 and Blocking RhoA/NF-κB Pathways in Human Intervertebral Disc Stem Cells. [Abstract]

2025 Oct 9;26(19):9819. PMID: 41097084
Ann Med

Human adipose-derived stem cells promote migration of papillary thyroid cancer cell via leptin pathway. [Abstract]

2024 Dec;56(1):2419990. PMID: 39450935
J Endocr Soc

2025 Dec 24.
Cancer Res Treat

Synergistic Activation of LEPR and ADRB2 Induced by Leptin Enhances ROS Generation in TNBC Cells. [Abstract]

2025 Apr;57(2):457-477. PMID: 39164083
Andrology

Cellular mechanism underlying leptin-induced anion secretion of rat epididymal epithelial cells. [Abstract]

2025 Feb;13(2):371-381. PMID: 38778669
bioRxiv

2026 Jan 05.
bioRxiv

2023 Aug 14.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (261 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Otvos L Jr, et al. Efficacy of a leptin receptor antagonist peptide in a mouse model of triple-negative breast cancer. Eur J Cancer. 2011;47(10):1578-1584. [Content Brief]

[2]. Coroniti R, et al. Designer Leptin Receptor Antagonist Allo-aca Inhibits VEGF Effects in Ophthalmic Neoangiogenesis Models [published correction appears in Front Mol Biosci. 2016 Nov 18;3:75]. Front Mol Biosci. 2016;3:67. Published 2016 Oct 13. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Allo-aca TFA

10 Cited Publications

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Activité biologique
- Description
- In Vitro
- In Vivo
Chemical Information
Publications (10)
Pureté et documentation
Références

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Allo-aca TFA

Publications Citing Use of MedChemExpress (MCE) Allo-aca TFA

Voir tous les produits spécifiques à Isoform Neuropeptide Y Receptor