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Cat. No.: HY-182782

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Analgesic agent-4

Analgesic agent-4 is an adenosine A₃AR ligand with analgesic/antinociceptive activity. Analgesic agent-4 inhibits writhing responses in mice and exhibits dose-dependent activity in the acetic acid (HY-Y0319)-induced mouse writhing model. Analgesic agent-4 can be used in the research of pain-related diseases.

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CAS No.: 1179703-17-3
Formule: C₁₁H₈ClN₃O₂
Masse moléculaire:249.65

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Please store the product under the recommended conditions in the Certificate of Analysis.

Analgesic agent-4 Chemical Structure

CAS No.: 1179703-17-3

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Activité biologique
- Description
- In Vitro
- In Vivo
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
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Activité biologique

Description

Voir tous les produits spécifiques à Isoform Adenosine Receptor :

In Vitro

Analgesic agent‑4 (Compound 37) can bind to the human adenosine A₃ receptor, and this binding relies on conserved and enhanced hydrophobic interactions^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Analgesic agent-4 (3-300 mg/kg; subcutaneous injection; single administration) exhibits analgesic activity in the mouse writhing model induced by Acetic acid (HY-Y0319)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Mice treated Acetic acid (HY-Y0319)^[1]
Dosage:

3-300 mg/kg
Administration:

s.c.; single dose
Result:

Produced a 47% writhing inhibition rate at 100 mg/kg.
Inhibited writhing in a dose-dependent manner within the range of 30-300 mg/kg.

Chemical Information

CAS No. 1179703-17-3
Masse moléculaire 249.65
Formule C₁₁H₈ClN₃O₂
SMILES

OC(C=C1)=CC=C1NC(C2=CC=C(Cl)N=N2)=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Mu Q, et al. Design, synthesis and evaluation of NTM-006-derived analgesics with enhanced potency. Bioorg Med Chem Lett. Published online March 30, 2026. [Content Brief]

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1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Analgesic agent-4

Voir tous les produits spécifiques à Isoform Adenosine Receptor

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

Analgesic agent-4 Related Classifications

HY-182782 Related Classifications